Biosynthesis ya proteoglycans na glycosaminoglycans imbere ya p-nitrophenyl-xyloside yakozwe hakoreshejwe uburyo bwambere bwimbeba ovarian granulosa sisitemu yumuco.Kwiyongera kwa p-nitrophenyl-xyloside mu muco w’akagari byatumye ubwiyongere bwa 700% bwa sulfate (ED50 kuri 0.03 mM) muri macromolecules, burimo iminyururu ya chondroitine yubusa yatangijwe kuri xyloside na proteoglycans kavukire.Iminyururu ya chondroitine sulfate yubusa yatangijwe kuri xyloside hafi ya yose yasohotse muburyo bwo hagati.Ingano ya molekuline ya chondroitine sulfate yagabanutse kuva ku 40.000 igera ku 21.000 kuko kwinjiza sulfate yose hamwe [35S] byongerewe imbaraga, byerekana ko kongera imbaraga za sulfate ya chondroitine byahinduye uburyo busanzwe bwo guhagarika urunigi rwa glycosaminoglycan.Biosynthesis ya heparan sulfate proteoglycans yagabanutseho hafi 50%, bishoboka ko biterwa no guhatanira kurwego rwa UDP-isukari ibanziriza.[35S] Kwinjiza sulfate byahagaritswe hiyongereyeho cycloheximide hamwe nigice cyambere cyambere cyamasaha 2 imbere ya xyloside, mugihe iyo xyloside idahari yari min 20.Itandukaniro rishobora kwerekana igipimo cyibicuruzwa bya glycosaminoglycan yoguhuza ubushobozi muri rusange.Igipimo cyibicuruzwa bya glycosaminoglycan yoguhindura ubushobozi bwagaragaye muri selile ovul granulosa yari ngufi cyane ugereranije n’ibyagaragaye muri chondrocytes, byerekana ubwiganze bugereranije bwibikorwa bya proteoglycan biosynthetic mubikorwa rusange byo guhinduranya ingirabuzimafatizo.
