Ibicuruzwa

2,3-Difluoro-4-ethoxybenzeneboronic aside ni uruganda rusanga ingirakamaro mubice byinshi bya chimie, cyane cyane muri synthesis organique na chimie miti.Hamwe nimiterere yihariye kandi ikora, yahindutse inyubako yingirakamaro yo gukora molekile zingirakamaro hamwe n’imiti ya farumasi. Kimwe mu bintu byingenzi byifashishwa na aside 2,3-Difluoro-4-ethoxybenzeneboronic aside iri mu ikoreshwa ryayo mu guhuza ibitekerezo.Imyitwarire ihuza abantu nka Suzuki-Miyaura na Buchwald-Hartwig, ni uburyo bukomeye bwo kubaka karubone-karubone na karubone-heteroatom.Muri ibyo bitekerezo, aside 2,3-Difluoro-4-ethoxybenzeneboronic aside irashobora kuba nk'ibigize ester ya boronate, ikora hamwe na electrophile zitandukanye (urugero, aryl halide, vinyl halide) bitewe na catalizator ikwiye.Ibi bifasha guhuza ibice bitandukanye bifite imiterere yibinyabuzima, nkibikoresho bya farumasi cyangwa ubuhinzi-mwimerere.Ikindi kandi, kuba hari atome ya fluor muri 2,3-Difluoro-4-ethoxybenzeneboronic aside irashobora gutanga ibintu byiza kuri molekile zavuyemo.Gusimbuza fluor birashobora kongera ituze, lipofilicite, hamwe na farumasi ya farumasi yibintu kama, bigatuma abakandida banywa ibiyobyabwenge bakora neza.Kubwibyo, gukoresha ingamba za 2,3-Difluoro-4-ethoxybenzeneboronic acide nkibibanziriza muguhuza ibice bisa nibiyobyabwenge birashobora gutanga uburyo bwo kubona molekile ya fluor hamwe nibikorwa bya biologiya hamwe nibyiza bya fiziki-chimique. Byongeye kandi, itsinda rya ethoxy riri muri 2 , 3-Difluoro-4-ethoxybenzeneboronic aside itanga ubundi buryo bwinshi muburyo bukoreshwa.Irashobora gukorerwa nucleophilique yo gusimbuza reaction, ikemerera kwinjiza amatsinda atandukanye akora kumwanya wa ethoxy.Ibi bifasha kuvanaho ibice kugirango bihuze imiterere yabyo kubwimpamvu zihariye cyangwa kumenyekanisha ingingo zinyuranye zinyuranye muguhuza isomero kugirango havumburwe ibiyobyabwenge.Mu ncamake, 2,3-Difluoro-4-ethoxybenzeneboronic acide ikora nkintera yingenzi muri synthesis organique na imiti yubuvuzi.Uruhare rwarwo muburyo bwo guhuza ibitekerezo, kwinjiza atome ya fluor, hamwe na derivatisation kuri ethoxy ituma iba igikoresho cyagaciro cyo kubaka ibinyabuzima bitandukanye bitandukanye bishobora gukoreshwa na farumasi.Imikoreshereze yacyo ituma synthesis ya molekile igoye hamwe namasomero yo kuvumbura ibiyobyabwenge kandi bigatanga uburyo bwa florine hamwe nibintu byiza.