2′-Deoxyuridine Cas: 951-78-0
| Umubare wa Cataloge | XD90583 |
| izina RY'IGICURUZWA | 2'-Deoxyuridine |
| URUBANZA | 951-78-0 |
| Inzira ya molekulari | C9H12N2O5 |
| Uburemere bwa molekile | 228.20 |
| Ibisobanuro birambuye | 2 kugeza 8 ° C. |
| Amategeko agenga ibiciro | 29349990 |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu yera kugeza yera |
| Suzuma | 99% |
| Ingingo yo gushonga | 164 - 168 Impamyabumenyi C. |
| Gutakaza Kuma | <1.0% |
| Ibisigisigi kuri Ignition | <0.1% |
Kunoza imikoreshereze ya azote mu nka ni ngombwa kugira ngo umusaruro w'inka urambye.Nkuko purine na pyrimidine (PP) bigize igice cyiza cya azote ya rumen, gusobanukirwa neza kwinjiza no guhinduranya hagati ya PP ni ngombwa.Igikorwa kiriho gisobanura iterambere no kwemeza uburyo bworoshye kandi bwihariye bwo kumenya icyarimwe purine 20 (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidine (cytosine, thymine, uracil, cytidine, uridine, thymidine, 2'-deoxyuridine), hamwe n’ibicuruzwa byabo byangirika (aside uric, allantoin, β-alanine, β-ureidopropionic aside, β-aminoisobutyric aside) muri plasma y’amaraso y’inka z’amata.Ubuhanga buhanitse bwa chromatografiya bushingiye ku buhanga bufatanije na electrospray ionisation tandem mass spectrometrie (LC-MS / MS) yahujwe na matrix ya matrike ihuye na kalibrasi hamwe na isotopic yanditseho ibintu bifatika.Yasesenguye ingano yabanjirijwe nuburyo bushya bwo kubanza kuvura bugizwe n’imvura ya Ethanol, kuyungurura, guhumeka no kwiyubaka.Ibipimo byo gutandukana no gutahura mugihe cya LC-MS / MS byakorewe iperereza.Hemejwe ko gukoresha moderi ya kalibibasi aho gukoresha umurongo wa kalibibasi yawo byatumye CV yo hasi kandi kubura ikizamini gikwiye byagaragaje gusubira inyuma.Uburyo bukubiyemo kwibanda kuri buri metabolite ukurikije ibyo mubitegererezo nyirizina, urugero nka guanine: 0.10-5.0 μ mol / L, na allantoin: 120-500 μ mol / L.CV% kumurongo watoranijwe yari munsi ya 25%.Uburyo bufite isubiramo ryiza (CV% ≤25%) hamwe no gutandukanya neza (CV% ≤25%) hamwe no gukira neza (91-107%).Metabolite yose yerekanaga ituze ryigihe kirekire kandi itajegajega imbere-ikora (CV% ≤10%).Impamyabumenyi zitandukanye zingaruka za matrixe yagaragaye muri plasma, inkari n'amata.Igenamigambi ryingaruka za matrix ryagaragaje ko ubwo buryo bwari bukwiye hafi ya zose zapimwe na metabolite ya PP muri plasma yakuwe mu mitsi hamwe na portal hepatike, hepatike na gastrosplenic vene kandi, usibye bake, no kubandi moko nkinkoko, ingurube, mink, umuntu n'imbeba.
