Ibicuruzwa

Trifluoroacetamide, hamwe na formulaire yimiti CF3CONH2, ni uruganda rusanga ibintu bitandukanye mubice bitandukanye, harimo imiti, imiti y’ubuhinzi, n’inganda. Mu nganda z’imiti, trifluoroacetamide igira uruhare runini nkitsinda ririnda synthesis.Kurinda amatsinda ni amatsinda akora yomwanya wigihe gito kuri atome yihariye muri molekile kugirango wirinde ingaruka zidakenewe mugihe cyo guhindura imiti.Trifluoroacetamide ikora nk'itsinda ririnda amine, cyane cyane amine y'ibanze.Mugukuramo amine yibanze hamwe na trifluoroacetamide, irinda neza reaction zidashaka, zemerera guhitamo guhitamo andi matsinda akora muri molekile.Izi ngamba zo kurinda-kwangiza zikoreshwa cyane muguhuza imiti igoye ya farumasi, ikemeza ko imiti yihariye igaragara gusa ahantu hateganijwe.Ikindi kandi, trifluoroacetamide ikoreshwa mugukora reagent ya Vilsmeier-Haack.Vilsmeier-Haack reaction ni imiti ikoreshwa muguhuza ibice bitandukanye kama, harimo aldehydes ya aromatic na ketone.Trifluoroacetamide, ifatanije na acide chloride na aside aside ya Lewis, ikora reagent ya Vilsmeier-Haack, ikora nkigikoresho kinini cyo gukora ibimera neza.Iyi reaction ikoreshwa cyane mubikorwa bya farumasi muguhuza abahuza nibindi bikoresho bya farumasi (APIs) .Mu rwego rwubuhinzi-mwimerere, trifluoroacetamide ikoreshwa nkigihe gito muguhuza imiti yica udukoko nudukoko.Imiterere yibikorwa ituma hashyirwaho amatsinda yihariye akenewe mubikorwa byubuhinzi.Molekile zishingiye kuri Trifluoroacetamide zirashobora kwerekana imiti yica ibyatsi cyangwa imiti yica udukoko ugereranije n’ibigereranyo byayo, bikongerera imbaraga mu kurinda ibihingwa ibyatsi bibi, ibyonnyi n’indwara.Ibikomoka kuri Trifluoroacetamide byagaragaje ibikorwa bikomeye birwanya ibinyabuzima bitandukanye mu gihe bigabanya ingaruka mbi ku bidukikije.Ikindi kandi, trifluoroacetamide ifite porogaramu mu nganda.Ifite uruhare mu gukora ibishishwa, nka N-methyl-N- (trifluoroacetyl) acetamide (MTAA), ikoreshwa mubikorwa bitandukanye byinganda.Trifluoroacetamide irimo ibishishwa bifite imitungo yifuzwa, harimo ingingo zitetse cyane, umuvuduko ukabije wumuyaga, hamwe n’imiti ihamye, bigatuma bikenerwa mubikorwa nko kuvoma, gutandukana, no kweza ibinyabuzima. Muri make, trifluoroacetamide igira uruhare runini muri synthesis organique, cyane mubikorwa bya farumasi nubuhinzi.Ikora nk'itsinda ririnda amine, ryemerera guhitamo mugihe cyo guhuza ibinyabuzima bigoye.Ibicuruzwa bishingiye kuri Trifluoroacetamide usanga bikoreshwa nkumuhuza mugukora imiti, imiti yica ibyatsi, nudukoko twangiza udukoko, bitanga umusaruro unoze kandi urambye kubidukikije.Byongeye kandi, trifluoroacetamide igira uruhare mukubyara imashanyarazi yihariye ikoreshwa mubikorwa bitandukanye byinganda.Guhindura byinshi hamwe na reactivite ya trifluoroacetamide bituma iba uruganda rwingirakamaro mubikorwa byinshi.