Tiamulin 98% Cas: 125-65-5
| Umubare wa Cataloge | XD91893 |
| izina RY'IGICURUZWA | Tiamulin 98% |
| URUBANZA | 125-65-5 |
| Imiterere ya molekularila | C22H34O5 |
| Uburemere bwa molekile | 378.5 |
| Ibisobanuro birambuye | -20 ° C. |
| Amategeko agenga ibiciro | 2918199090 |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu yera |
| Assay | 99% min |
| Ingingo yo gushonga | 170-1710C |
| alfa | D24 + 20 ° (c = 3 muri abs etanol) |
| Ingingo yo guteka | 482.8 ± 45.0 ° C (Biteganijwe) |
| ubucucike | 1.15 ± 0.1 g / cm3 (Biteganijwe) |
| gukemura | DMSO:> 10mg / mL (ashyushye) |
| pka | 12.91 ± 0.10 (Biteganijwe) |
| ibikorwa byiza | [α] / D +30 kugeza + 40 ° (c = 1; CH2Cl2) |
Pleuromutilin ni diterpene ikorwa nubwoko butandukanye bwa basidomycete, cyane cyane ubwoko bwa Pleurotus, bwavumbuwe mu 1951. Pleuromutilin ni antibiyotike ikomeye kandi ihitamo cyane ikora kurwanya bagiteri nyinshi za Gram nziza, nta kurwanya umusaraba uhari bitewe nuburyo bwihariye bwayo. Bya Igikorwa.Pleuromutilin ibuza intungamubiri za poroteyine guhuza na domaine V ya 23S rRNA kandi ibyo byatumye habaho iterambere ryinshi rigereranya nka antibiyotike yo mu gisekuru gishya, nka tiamuline na retapamuline.
Pleuromutiline nka tiamuline na valnemuline imaze igihe ikoreshwa mu buvuzi bw'amatungo mu kuvura indwara z'ingurube.Vuba aha, semisynthetic pleuromutilin, retapamulin, yatangijwe nkumuti wibanze wanduye Gram-positif kubantu.Pleuromutiline ibuza ibikorwa byo kohereza peptidyl ya bagiteri 50S ribosomal subunit ihuza urubuga A.
