Ibicuruzwa

Tert-butyl 4- (6 - ((6- (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate ni uruganda rufite imbaraga nyinshi muri chimie yimiti no guteza imbere ibiyobyabwenge.Imiterere ya molekuliyumu igoye yerekana uburyo butandukanye bushobora gukoreshwa.Iyi nteruro irimo piperazine-1-ya karubasi ya karubasi, ikaba ikunze gukoreshwa muri chimie yimiti kubera imiterere yayo itandukanye hamwe n’ibiyobyabwenge byinshi bishoboka.Kubaho kwa piperazine bituma habaho imikoranire hamwe na reseptor na enzymes zitandukanye, bigatuma iba umukandida ushimishije mugutezimbere imiti ivura. 6- (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido [2,3-d] pyrimidin-2-yl mumatsinda itanga ibikorwa bya farumasi.Ibikomoka kuri pyrido [2,3-d] ibikomoka kuri pyrimidine byakozweho ubushakashatsi bwimbitse kubiranga anti-inflammatory, antiviral, na anticancer.Amatsinda ya cyclopentyl na methyl agira uruhare muri lipophilicity yikigo, gishobora kongera ubushobozi bwimikorere ya selile na bioavailability.Itsinda rya tert-butyl ester ritanga ituze kumurongo kandi rishobora guhindurwa byoroshye mumatsinda yandi mikorere, ryemerera guhinduka cyangwa kubyara.Ihindagurika rifite agaciro muri chimie yubuvuzi, kuko ituma habaho iterambere ryinshi ryinshi kandi ritoranya.Itsinda rya pyridin-3-yl mumiterere ikora nka ligand ishobora kuba yakira ibintu bitandukanye, nka G proteine ​​zifatanije na GPCRs.Ibi birerekana ko uruganda rushobora kugira ingaruka kumihanda yerekana ibimenyetso kandi rushobora kurushaho gushakishwa kubushobozi bwarwo nka modulator cyangwa antagonisti ya reseptors yihariye igira uruhare mubibazo byindwara. Imiterere rusange ya tert-butyl 4- (6 - ((6-) (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido ubushobozi bwayo mugutezimbere imiti yubuvuzi.Itanga amahirwe yo gukora iperereza kubuza enzyme, guhuza reseptor, no guhindura uburyo butandukanye bwibinyabuzima. Hamwe nubushakashatsi bunoze kandi bunoze, uru ruganda rushobora kuba intandaro yo guteza imbere imiti yibasira kanseri, gutwika, cyangwa izindi ndwara.Ibiranga imiterere yihariye nibikorwa byubuzima bwa biologiya bituma iba urwego rushimishije rwo gukomeza ubushakashatsi niterambere mubijyanye na chimie miti.Mu gusoza, tert-butyl 4- (6 - ((6- (1-butoxyvinyl) -8-cyclopentyl- 5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate isezeranya nkibintu byinshi bigamije iterambere ryibiyobyabwenge.Imiterere igoye hamwe nibikorwa bya farumasi bituma iba umukandida ushishikaje kugirango hakorwe iperereza nkumuntu ushobora kuvura indwara zitandukanye.