Ibicuruzwa

Trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3-karubasi ya acide ni imiti ivanga imiti itandukanye, cyane cyane muri synthesis organique nubushakashatsi bwa farumasi.Imiterere yacyo igizwe nimpeta ya pyrrolidine yasimbujwe nitsinda rya amino hamwe na tert-butoxycarbonyl (Boc) irinda itsinda kuri atome ya azote. Bumwe mu buryo bwibanze bwo gukoresha trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3- acide karubike ni nkibice byubaka muguhuza molekile zigoye.Kubaho kwitsinda rya amino ryemerera guhindura imiti myinshi, harimo amidation, acylation, cyangwa reaction reaction, aribyingenzi mukurema ibice bitandukanye bifite imiti yihariye cyangwa imiti.Itsinda ririnda Boc ririnda itsinda rya amino mugihe cyibisubizo, birinda imikoranire idakenewe cyangwa kuruhande. ibiyobyabwenge.Peptide ni iminyururu ngufi ya aside amine igira uruhare runini mubikorwa byibinyabuzima.Muguhitamo gutesha agaciro itsinda rya Boc, uruganda rushobora kuba nka aside amine yubaka kugirango yubake peptide.Ibi bituma habaho imiti ishingiye kuri peptide, ishobora kwibasira intego yihariye ya molekile, nka reseptor cyangwa enzymes, kandi igahindura inzira zitandukanye zibinyabuzima.Iyi miti yerekanye amasezerano mubice nko kuvura kanseri, kuvura mikorobe, hamwe n’imivurungano ya hormone. Ubwinshi bw’imvange kandi bugera no mubushobozi bwayo nkibikoresho byo gutangiza sintezike ya molekile ntoya hamwe nibikorwa byibinyabuzima.Mugukoresha amatsinda akora hamwe na stereochemie ya trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3-karubasi ya acide, abashakashatsi barashobora gukora ibigereranyo cyangwa ibiyikomokaho bifite imiti yongerewe imiti.Ibi bikoresho byahinduwe birashobora kugenzurwa kubashobora kuba abakandida ibiyobyabwenge, bigasuzumwa kubushobozi bwabo bwo guhuza intego yibinyabuzima, cyangwa bigakorerwa kumikoreshereze yabyo. Byongeye kandi, trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3-karubasi ya aside irashobora gukoreshwa nkibisobanuro bifatika bigamije gusesengura.Imiterere ihamye hamwe nimiterere irangwa neza bituma igira agaciro nkigipimo cyiza cyo kugenzura ubuziranenge munganda zimiti, cyemeza neza kandi cyizewe cyuburyo bwisesengura bwakoreshejwe mugusuzuma ubuziranenge nimbaraga zibintu bifitanye isano.Mu gusoza, trans-4-Amino-1- .Imiterere yacyo isa na aside amine hamwe nitsinda ririnda bituma iba inyubako yingenzi yo gukora molekile zigoye, harimo peptide hamwe n’abakandida ibiyobyabwenge.Iperereza rigikomeje kumiterere yaryo no kuyihindura bizakomeza kwagura ibikorwa byayo no kugira uruhare mugutezimbere imiti ivura imiti.