Ibicuruzwa

Gukora iperereza ku ngaruka zamavuta ya spearmint kumpinduka zisa na emphysema no kwerekana ibibyimba necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) hamwe na tissue inhibitor ya metalloproteinase -1.Imbeba zagabanyijwemo kugenzura, dexamethasone (0,3 mg x kg (-1)), hamwe n’amavuta y’icumu (10, 30.100 mg x kg (-1)).Buri tsinda ryavuwe hamwe na saline, dexamethasone, hamwe nicumu ryamavuta mugihe cyibyumweru 4.Hanyuma, umubare wuzuye kandi utandukanye wamaraso yera muri bronchoalveolar lavage fluid (BALF).Imihindagurikire y’indwara zifata ibihaha nk'imiterere ya alveolar, gutwika umwuka, hamwe na metaplasia ya goblet selile byagaragaye na HE na AB-PAS.Hagaragajwe imvugo ya TNF-alpha, IL-1beta, TIMP-1 na MMP-9. Icumu ryombi na dexamethasone byagabanije kurimbuka kwa alveolus.Umubare wuzuye kandi utandukanye wamaraso yera muri BALF harimo neutrophile na lymphocyte yamavuta ya spearmint 100 mg x kg (-1) hamwe nitsinda rya dexamethasone ryaragabanutse cyane, kandi metaplasia selile ya goblet nayo yarabujijwe.Dexamethasone yagize ingaruka zo guhagarika imvugo ya TNF-alpha, IL-1beta, TIMP-1 na MMP-9.Amavuta ya spearmint 30, 100 mg x kg (-1) yagabanije cyane TNF-alpha na IL-1beta.Amavuta ya spearmint 10, 30 na 100 mg x kg (-1) nta ngaruka yagize ku mvugo ya TIMP-1, ariko ashobora kugabanya imvugo ya MMP-9 ku buryo bugaragara mu ngingo z’ibihaha. kubera ko iteza imbere kurimbuka kwa alveolar, gutwika ibihaha, na metaplasia selile.Ubwo buryo bushobora kubamo kugabanya TNF-alpha, IL-1beta no kubuza gukabya gukabije kwa matrix metalloproteinase-9 mu ngingo zifata ibihaha.