Ibicuruzwa

L-Ascorbic Acide, Kalisiyumu Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Fosifate, Sodium Ascorbate, na Sodium Ascorbyl Fosifate ikora muburyo bwo kwisiga cyane cyane nka antioxydants.Acide ya Ascorbic bakunze kwita Vitamine C. Acide ya Ascorbic ikoreshwa nka antioxydeant na pH igabanya imiti myinshi yo kwisiga, hejuru ya 3/4 muri byo byari amarangi yimisatsi namabara yibitekerezo biri hagati ya 0.3% na 0,6%.Kubindi bikoreshwa, amakuru yibanze yaba make cyane (<0.01%) cyangwa murwego rwa 5% kugeza 10%.Kalisiyumu Ascorbate na Magnesium Ascorbate isobanurwa nka antioxydants hamwe nubushakashatsi bwuruhu - bitandukanye kugirango bikoreshwe mu kwisiga, ariko ntibikoreshwa ubu.Sodium Ascorbyl Fosifate ikora nka antioxydeant mu bicuruzwa byo kwisiga kandi ikoreshwa mubitekerezo biri hagati ya 0.01% na 3%.Magnesium Ascorbyl Fosifate ikora nka antioxydeant mu kwisiga kandi byavuzwe ko ikoreshwa kuri concentration kuva 0.001% kugeza 3%.Sodium Ascorbate nayo ikora nka antioxydeant yo kwisiga yibanda kuri 0.0003% kugeza 0.3%.Ibikoresho bifitanye isano (Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate, Acide Erythorbic, na Sodium Erythorbate) byasuzumwe mbere n’inama y’impuguke ya Cosmetic Ingredient Review (CIR) basanga "ari byiza gukoreshwa nkibikoresho byo kwisiga mubikorwa byubu byibyiza. koresha. "Acide ya Ascorbic ni ikintu kizwi cyane nk'umutekano (GRAS) kugirango ukoreshwe nk'imiti igabanya ubukana mu biribwa kandi nk'intungamubiri kandi / cyangwa inyongera y'ibiryo.Kalisiyumu Ascorbate na Sodium Ascorbate byashyizwe ku rutonde nkibintu bya GRAS kugirango bikoreshe imiti igabanya ubukana.L-Ascorbic Acide iroroshye kandi ihindagurika kuri aside L-dehydroascorbic kandi ubwo buryo bwombi bubaho muburinganire mumubiri.Igipimo cya Acide ya Ascorbic ikoresheje uruhu rwimbeba zose kandi zambuwe ni 3.43 +/- 0,74 microg / cm (2) / h na 33.2 +/- 5.2 microg / cm (2) / h.Ubushakashatsi bukabije bwo mu kanwa no kubabyeyi mu mbeba, imbeba, inkwavu, ingurube, imbwa, ninjangwe byagaragaje uburozi buke.Ascorbic Acide na Sodium Ascorbate yakoze nka inhibitor ya nitrosation mubushakashatsi bwibiribwa byinshi no kwisiga.Nta bimenyetso bifitanye isano n’amavuriro cyangwa ingaruka zikomeye cyangwa microscopique y’indwara zagaragaye haba mu mbeba, imbeba, cyangwa ingurube mu bushakashatsi bw’igihe gito.Ingurube z'igitsina gabo zagaburiraga ibiryo byibanze kandi bigatanga mg zigera kuri 250 Acide ya Ascorbic mu kanwa ibyumweru 20 yari ifite hemoglobine, glucose yamaraso, serumu fer, fer yumwijima, hamwe numwijima glycogene ugereranije nagaciro kagenzura.Imbeba z'abagabo n'abagore F344 / N n'imbeba za B6C3F (1) zagaburiwe ibiryo birimo Acide ya Ascorbic igera ku 100.000 ppm mu byumweru 13 bifite uburozi buke.Ubushakashatsi bwibiryo bya Ascorbic Chronic bwerekanye ingaruka zuburozi kuri dosiye iri hejuru ya 25 mg / kg uburemere bwumubiri (bw) mu mbeba ningurube.Amatsinda yimbeba zabagabo nigitsina gore zitangwa buri munsi kugeza kuri 2000 mg / kg bw Ac Ascorbic Acide kumyaka 2 ntabwo yari ifite macro- cyangwa microscopique yanduye uburozi.Imbeba zahawe Ascorbic Acide munsi yumubiri no mumitsi ya buri munsi (500 kugeza 1000 mg / kg bw) muminsi 7 ntabwo byahindutse mubushake bwo kurya, kwiyongera ibiro, nimyitwarire rusange;no gusuzuma amateka yingingo zitandukanye ntagaragaza impinduka.Acide ya Ascorbic yari fotoprotectant iyo ikoreshejwe imbeba nuruhu rwingurube mbere yo guhura nimirasire ya ultraviolet (UV).Hagaragaye kandi kubuza UV iterwa no guhagarika hyperensitivite.Ubuyobozi bwa Magnesium Ascorbyl Phosphate ako kanya nyuma yo guhura nimbeba zitagira umusatsi byadindije cyane kwibibyimba byuruhu hamwe na hyperplasia iterwa no guhura nimirasire ya UV.Imbeba n'imbeba zitwite byahawe buri munsi dosiye yo mu kanwa ya Acide ya Ascorbic igera kuri mg / kg 1000 bw nta kimenyetso cyerekana ingaruka z'abantu bakuru-uburozi, teratogenic, cyangwa fetotoxic.Acide ya Ascorbic na Sodium Ascorbate ntabwo yari genotoxique muri sisitemu nyinshi zo gupima za bagiteri n’inyamabere, zihuza na antioxydeant yiyi miti.Imbere ya sisitemu zimwe na zimwe za enzyme cyangwa ion zicyuma, ibimenyetso bya genotoxicity byagaragaye.Gahunda y’igihugu y’uburozi (NTP) yakoze imyaka 2 bioassay yo mu kanwa kanseri yo mu kanwa ya Acide ya Ascorbic (25.000 na 50.000 ppm) mu mbeba F344 / N n'imbeba B6C3F (1).Acide ya Ascorbic ntabwo yari kanseri mu mibonano mpuzabitsina yombi n'imbeba.Birabujijwe kubuza kanseri no gukura kw'ibibyimba bijyanye na antioxydeant ya Ascorbic Acide.Sodium Ascorbate yerekanwe guteza imbere iterambere rya kanseri yinkari mu byiciro bibiri bya kanseri.Gukoresha dermal Acide ya Ascorbic kubarwayi barwaye imirasire ya dermatite hamwe nabatwitswe nta ngaruka mbi.Acide ya Ascorbic yari fotoprotectant mubushakashatsi bwubuvuzi bwa muntu UV ku kigero kiri hejuru ya dose ya erythema (MED).Amavuta meza arimo aside 5% ya Ascorbic ntabwo yateje ubukangurambaga bwa dermal mubintu 103 byabantu.Igicuruzwa kirimo Acide ya Ascorbic 10% nticyari cyarakaye mugihe cyiminsi 4 minicumulative patch yipimishije kuruhu rwabantu kandi kuvura mumaso birimo 10% Acide ya Ascorbic ntabwo byari sensibilité de contact muburyo bukabije bwakorewe abantu 26.Kubera imiterere n'imikorere bisa nibi bikoresho, Akanama kizera ko amakuru ku kintu kimwe ashobora koherezwa kuri bose.Akanama k'impuguke kavuze ko ubushakashatsi bwakozwe bwerekana ko Acide ya Ascorbic yari genotoxique muri ubwo buryo buke bwo kwisuzumisha bitewe no kuba hari indi miti, urugero, ibyuma, cyangwa sisitemu zimwe na zimwe za enzyme, ibyo bikaba bihindura neza imikorere ya anti -xydeant ya Ascorbic Acide na por-oxydeant.Iyo Acide ya Ascorbic ikora nka antioxydeant, Akanama kanzuye ko Acide ya Ascorbic atari genotoxique.Gushyigikira iki gitekerezo ni ubushakashatsi bwa kanseri bwakozwe na NTP, butagaragaza ibimenyetso byerekana kanseri.Acide ya Ascorbic yabonetse kugirango ibuze umusaruro wa nitrosamine muri sisitemu nyinshi zo kwipimisha.Itsinda ryasuzumye ubushakashatsi aho Sodium Ascorbate yakoraga nk'ibibyimba mu nyamaswa.Ibisubizo byafatwaga nkaho bifitanye isano nubunini bwa sodium ion na pH yinkari mu nyamaswa zapimwe.Ingaruka nkizo zagaragaye hamwe na sodium bicarbonate.Kubera impungenge z'uko ion zimwe na zimwe z'icyuma zishobora guhuriza hamwe n'ibiyigize kugira ngo bitange ibikorwa bya poroteyine, Panel yihanangirije abayikora kugira ngo bamenye neza ko ibyo bikoresho bikora nka antioxydants mu kwisiga.Akanama kemeje ko uburambe bw’amavuriro bwakoreshejwe na Acide ya Ascorbic ku ruhu rwangiritse nta ngaruka mbi kandi ikizamini cyo gusubiramo-gutukana (RIPT) ukoresheje 5% ya Ascorbic Acide hamwe n’ibisubizo bibi bishyigikira ko iri tsinda ryibigize ridatanga a ibyago byo gukangurira uruhu.Aya makuru ajyanye no kubura raporo mubitabo byubuvuzi bya Ascorbic Acide sensibilisation ishyigikira cyane umutekano wibigize.