Ibicuruzwa

Ibikoresho byinshi bigenda bikurikiranwa kugirango bivure neza indwara zitoroshye.Hano, turasobanura igishushanyo mbonera hamwe na synthesis yicyiciro gishya cyibivange bya shogaol-huprine, bivugwa ko byibasiye intego nyamukuru zagize uruhare mu ndwara ya Alzheimer.Imvange zapimwe muri vitro kubikorwa byazo byo kubuza kurwanya acetylcholinesterase yumuntu na butyrylcholinesterase nigikorwa cya antioxydeant (ABTS.Na none, hasuzumwe ubwonko bwabo bwinjira (PAMPA-BBB assay).Nubwo imvange zidafite imbaraga za AChE inhibitor cyangwa antioxydeant nka bababyeyi huprine Y na [4] -shogaol, baracyerekana ibikorwa bikomeye bya anticholinesterase na antioxydeant kandi bifite imbaraga nyinshi Aβ42 na tau anti-agregateur kurusha iya ibice byababyeyi.Muri rusange, imvange ya shogaol-huprine igaragara nkubwonko bushimishije ubwonko bwinjira muri multitarget anti-Alzheimer.

Ibikomoka kuri polarite itandukanye yabonetse mubice bitandukanye byibimera (umuzi, amababi, indabyo n'imbuto) bya Seseli rigidum byakozwe nubushakashatsi butandukanye bwa antioxydeant: DPPH na ABTS ibikorwa byo gusiba bikabije, hakoreshejwe uburyo bwo kugabanya ingufu zose hamwe nibirimo byose bya flavonoide na polifenole .Amavuta yingenzi yibice byose byibimera yerekanaga intege nke za antioxydeant.Ikigereranyo cyo kubuza ibimera byakorewe ibizamini, kurwanya bagiteri Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, na fungi Candida albicans na Aspergillus niger yari 0.01-1.50 mg / mL na mikorobe 0.02-3.00 mg / mL.Mu mikoranire na cholinesterase, amavuta yose yingenzi yagaragaye nkingirakamaro.Ijanisha ryinshi ryo kubuza hamwe na cholinesterase yumuntu nifarashi ryerekanwe namavuta yingenzi yumuzi (38,20% na 48,30%), hamwe namavuta ya hexane (40.56% na 50.65%).Amavuta yingenzi nibice bihindagurika byibice byose byibimera byamenyekanye na GC, GC-MS n'umwanya wumutwe / GC-MS.Isesengura mibare ryitsinda ryibisubizo ryerekanye ko umuzi wibanze wamavuta atandukanye cyane namavuta yingenzi yibindi bice byigihingwa.Urebye ibikorwa byose byizewe, umuzi wa hexane werekanye ibintu byiza muri rusange.Hifashishijwe uburyo bwo hejuru bwamazi ya chromatografiya ihujwe no gukemura cyane ya mass spectrometrie, ibice 30 byiganjemo byinshi byagaragaye mubice bivamo polarite zitandukanye.Kuba haribintu byatoranijwe byari bifitanye isano nibikorwa byihariye byibinyabuzima, bityo bikerekana ibice bishobora kuba inshingano kuri buri gikorwa cyerekanwe.