Ibicuruzwa

eucine ikungahaye cyane gusubiramo kinase 2 (LRRK2) ihinduka ni yo mpamvu izwi cyane itera indwara ya Parkinson (PD).Ibiranga ivuriro rya LRRK2 PD ntaho bitandukaniye na PD idasanzwe, hamwe no kwegeranya α-synuclein na / cyangwa tau na / cyangwa ubiquitin muri rusange.Ibi birerekana ko LRRK2 ari urufunguzo rwo gusobanukirwa aetiologiya yiyi ndwara.Nubwo gutakaza-imikorere-bitagaragara nkuburyo butera PD abarwayi ba LRRK2, ntibisobanutse uburyo iyi proteyine ihuza uburozi.Muri ubu bushakashatsi, turatangaza ko LRRK2 gukabya gukabije mu tugari no muri vivo byangiza ibikorwa byinzira ya ubiquitin-proteasome, kandi ko ibyo bigira uruhare mu gukusanya insimburangingo zitandukanye hamwe na LRRK2 ikabije.Twerekana ko ibyo bidahuzwa na LRRK2 nini cyangwa se gukurikiranya ubiquitin kuri agregate.Icyangombwa, ibintu bidasanzwe ntibigaragara hamwe no gukabya gukabije kwa poroteyine LRRK1.Amakuru yacu yerekana ko LRRK2 ibuza gukuraho proteasome substrate s hejuru yibikorwa bya proteasome catalitike, bigatuma habaho gukusanya poroteyine no kwibumbira hamwe.Rero, dutanga molekile ihuza LRRK2, ikunze kumenyekana cyane itera PD, hamwe na fenotipike yasobanuwe mbere yo kwirundanya kwa poroteyine.