Orlistat Cas: 96829-58-2
| Umubare wa Cataloge | XD91190 |
| izina RY'IGICURUZWA | Orlistat |
| URUBANZA | 96829-58-2 |
| Inzira ya molekulari | C29H53NO5 |
| Uburemere bwa molekile | 495.73 |
| Ibisobanuro birambuye | 2 kugeza 8 ° C. |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu yera |
| Assay | 99% |
Kugabanya ibiro bishya no kugabanya lipide: Orlistat ni ubwoko bushya bwo kugabanya ibiro hamwe n’ibiyobyabwenge bigabanya lipide bizwi ku rwego mpuzamahanga.Hamwe no kugurisha buri mwaka miliyoni 538 US $, orlistat kuri ubu ifata 80% by isoko ryo kugabanya ibiro ku isi, naho kugurisha buri mwaka muri Hong Kong, Ubushinwa byonyine bigera kuri miliyoni 80 USD.Kuri ubu niwo muti wonyine wo kugabanya ibiro bya OTC kwisi.Abantu barenga 40.000.000 kwisi barabitwaye kandi baratsinze neza.Kugeza ubu nigicuruzwa cyagurishijwe cyane cyo kugabanya ibiro.Nibyiza kugabanya ibiro.Orlistat ni imbaraga kandi ndende-ndende ikora gastrointestinal lipase inhibitor.Muguhagarika mu buryo butaziguye umubiri kwinjiza ibinure mu biryo, iyo gufata karori n'ibinure bitarenze ibyo kurya, ibinure byumubiri biragabanuka, kugirango bigere ku ntego yo kugabanya ibiro.Ni byiza kugabanya ibiro, ibintu bikora ntabwo byinjira mu maraso, kandi ntibikora kuri sisitemu yo hagati.
Orlistat ni ndende-ikomeye kandi ikomeye cyane ya gastrointestinal lipase inhibitor, ifu yera cyangwa yera yera mubushyuhe bwicyumba, idashonga mumazi, igashonga muri chloroform, kandi igashonga byoroshye muri Ethanol.Imbuga za serine zikora za lipase gastric na pancreatic lipase zikora covalent bonds kugirango idakora enzymes.Ibinure biri mu biryo ntibishobora kubora aside irike yubusa na monoacylglycerol, bityo ibinure ntibishobora kwinjizwa no gukoreshwa, bityo bikagabanya kalori yumubiri kandi bikagenzura uburemere bwumubiri.Uyu muti ntusaba kwinjiza sisitemu kugirango ukore.Mugihe gisanzwe, kwinjiza ibinure birashobora guhagarikwa na 30%.Ntibisanzwe byinjira nyuma yubuyobozi bwo mu kanwa, kandi birashobora kudakorwa na metabolism mumyanya yo mara.Ikibanza cya metabolike kiri murukuta rwinzira ya gastrointestinal, kandi kurandura igice cyubuzima ni amasaha 14 kugeza 19.Ibicuruzwa bigera kuri 97% bisohoka hamwe n umwanda, muri byo 83% bisohoka muburyo bwumwimerere.
Irashobora gukoreshwa mubuvuzi mubyibushye hamwe na hyperlipidemiya.Mubihe bisanzwe, ikinini cya mg 120 gishobora gufatwa kumunwa, gatatu kumunsi, hamwe nifunguro cyangwa isaha 1 nyuma yo kurya.Ibiro birashobora gutangira kugabanuka nyuma yibyumweru 2 ufashe ibiyobyabwenge.Irashobora gufatwa ubudahwema amezi 6 kugeza 12.Niba igipimo cyiyongereye kugera kuri mg zirenga 400 kumunsi, ingaruka zacyo ntizizongera.
