amakuru

Neocuproine reagent ni reagent yo kumenya umuringa, umweru cyangwa umuhondo-umukara kristu, irakaza.Ahanini ikoreshwa nka reagent yo kumenya igikombe, kugena amafoto yumuringa, kugena isukari yamaraso ya ultra-micro;synthesis organic.Neocuproine hydrochloride monohydrate yakoreshejwe mugupima isenyuka ryumuringa muri Cu - Ni alloys hakoreshejwe uburyo bwa colimetric.Yarakoreshejwe kandi mugutegura igisubizo kitoroshye cyo gukemura ikibazo cyo kwiga ubushobozi bwa antioxydeant mubushakashatsi bwibinyabuzima bushingiye kuri Cu kugabanya ibigo.Irashobora gukoreshwa nkibibanziriza gutegura neocuproine, ikoreshwa nka reagent yisesengura kugirango hamenyekane umuringa mubitegererezo by’ibidukikije ukoresheje tekinike ya spekitifoto.

Nyamara gusa imiti nkiyi ifite imikoreshereze itandukanye cyane mubuvuzi.Mu minsi ishize, Eribulin yemerewe gucuruzwa n’ikigo cy’igihugu gishinzwe ibicuruzwa by’ubuvuzi (NMPA) cy’igihugu cyanjye kugira ngo bivurwe n’abarwayi ba kanseri y'ibere yisubiramo cyangwa metastatike yakiriye nibura chimiotherapie ebyiri gahunda (harimo anthracycline na tagisi) kera.Yazanye uburyo bushya bwo kuvura mubijyanye na chimiotherapie ya kanseri y'ibere mu Bushinwa, Bizana kandi uburyo bwo kuvura abarwayi.
Eribuline ni inhibitori ya tubuline.Bitandukanye na tagisi na vinblastine tubulin inhibitor, Eribulin ifite uburyo bwihariye bwibikorwa, bigatuma Eribuline Iracyakora neza kubarwayi nyuma yo kurwanya ibiyobyabwenge yew;Eribuline kandi ifite ingaruka zitari cytotoxique, harimo kuvugurura imitsi, kongera ububobere buke bwibiyobyabwenge muri microen ibidukikije yibibyimba, guhuza imiti, no guhindura ingirabuzimafatizo yibibyimba Inzibacyuho ya epidermal-mesenchymal nibindi.

Uhereye kuri synthesis yose ya halichondrin B, gukoresha reagent nshya yumuringa nkumuhuza, kugeza guhindura imiterere ya Eribulin, kugeza ku nganda zikora inganda za Eribulin, abahanga bo muri za kaminuza n’amasosiyete yimiti bamaze imyaka irenga 20 bakora ubushakashatsi.Ibicuruzwa bisanzwe biva mu nyanja byahindutse ibiyobyabwenge bishobora kuvura kanseri.Ubushakashatsi niterambere rya Eribulin ni ukubera ko reagent nshya y'umuringa ari ntangarugero nkumuhuza nyamukuru wa API yayo.Umuringa mushya wumuringa ufite uruhare runini nka farumasi yimiti na reagent yo koza ibikoresho byo murwego rwohejuru.

Imiterere ya molekuline ya Eribuline irimo ibigo 19 bya chiral, kandi intambwe ya synthesis ni ndende nkintambwe 62.Kugeza ubu, Eribulin iracyafatwa n’inganda nkumuti ukomeye cyane utari peptide ukorwa na synthesis yimiti itunganijwe, kandi ushobora kwitwa umusozi wa Everest munganda zikora imiti.
Urutonde rwiza rwa Eribulin rugaragaza uburebure bushya uruganda rukora imiti rushobora kugeraho muguhuza imiti n’umusaruro w’inganda.Bizana kandi ibitekerezo byinshi byo gusuzuma no kuvura hamwe namahitamo kubavuzi bo mubushinwa.Twizera ko mu mavuriro azaza, imiti mishya ya chimiotherapeutique Eribulin ishobora kuzana ibyiringiro bishya ku barwayi ba kanseri y'ibere.