Ibicuruzwa

Methyl 1 - [((2 ' umuryango wibikomoka kuri benzimidazole, bigenzurwa cyane kubushobozi bwabo bwo kuvura.Benzimidazoles yasanze yerekana ibikorwa byinshi byibinyabuzima, harimo anticancer, antifungal, antibacterial, antiviral, na anti-inflammatory. Methyl 1 - [(2'-cyanobiphenyl-4-yl) methyl] -2-ethoxy-1H -benzimidazole-7-carboxylate irashobora kuba nk'urwego rwibanze rwo gushushanya no guteza imbere imiti mishya.Imiterere yihariye ya chimique itanga amahirwe yo kurushaho guhindura no gutezimbere kugirango wongere ibikorwa bya farumasi wifuza cyangwa ugamije inzira zindwara zihariye.Abashinzwe imiti barashobora gukoresha iyi nteruro nkintangiriro yo guhuza molekile yubushakashatsi hamwe nibishobora kuvurwa.Mu kumenyekanisha insimburangingo ikwiye ya chimique cyangwa amatsinda yimikorere kumiterere yibanze, abashakashatsi barashobora gukora inkomoko ifite imbaraga zinoze, guhitamo, hamwe na farumasi yubuzima.Izi mpinduka zirashobora kongera imbaraga zingirakamaro muguhitamo uburyo bwihariye bwindwara cyangwa intego za molekuline, biganisha ku iterambere ryimiti ikora neza.Ubushakashatsi nubushakashatsi birashobora gukorwa kugirango harebwe ibikorwa byibinyabuzima by’uruganda hifashishijwe ubushakashatsi bwakozwe na vitro selile cyangwa mubyitegererezo by'inyamaswa za vivo.Ibi birashobora gutanga ubushishozi mubikorwa byokuvura bishobora gukoreshwa no kuyobora kurushaho gutezimbere.Ikindi kandi, iyi nteruro irashobora kuba igikoresho cyingirakamaro mukwiga imiterere-ibikorwa byimikorere (SAR) bikomoka kuri benzimidazole.Mugushushanya ibigereranyo hamwe nuburyo butandukanye mumurongo wuruhande cyangwa mumatsinda ikora, abahanga barashobora gusobanukirwa neza nuburyo ihinduka ryimiterere ryihariye rigira ingaruka kumikorere no guhitamo.Ubu bumenyi bushobora gufasha mugushushanya gushyira mu gaciro abakandida b’ibiyobyabwenge bakomeye kandi batoranya.Ikindi kandi, iyi nteruro irashobora gukoreshwa mugutezimbere prodrugs, aho itsinda rya ethoxy rishobora guhitamo neza, kurekura ibiyobyabwenge bikora kurubuga rwabigenewe.Prodrugs itanga ibyiza nko kunonosora imbaraga, kongera bioavailable, hamwe no gutanga imiti yihariye, bityo bigahindura imikorere yibiyobyabwenge no kugabanya ingaruka mbi.Nyamara, ni ngombwa kumenya ko ubushakashatsi bwimbitse, isuzumabumenyi ryuzuye, hamwe nubushakashatsi bukomeye bwumutekano nuburozi birakenewe mbere yo gusuzuma ibice byiterambere ryamavuriro.Ibi nibyingenzi kugirango umutekano wacyo, imikorere, hamwe nuburyo bukoreshwa muburyo bwo kuvura.Mu gusoza, Methyl 1 - ibice byinshi hamwe nibishobora gukoreshwa mubijyanye na farumasi.Imiterere yihariye n'imiti itanga amahirwe yo kuvumbura ibiyobyabwenge, gukora neza, no guteza imbere prodrugs.Nyamara, ubushakashatsi nubushakashatsi byiyongereye birasabwa gushakisha byimazeyo ubushobozi bwo kuvura no kubungabunga umutekano wabwo kugirango bikoreshe amavuriro.