Ibicuruzwa

Uburyo bwo kuvura T2DM, indwara irangwa nubusembwa bubiri bwimikorere mibi ya selile islet hamwe no kurwanya insuline, harimo ibintu byongera imisemburo ya insuline na pancreas (secretagogues), imiti yongerera imbaraga ingingo zigenewe insuline (sensitizers), na imiti igabanya igipimo cyo kwinjiza glucose ituruka mu nzira ya gastrointestinal.Liraglutide, GLP-1 reseptor agonist kugirango agere ku isoko, afite homologiya 97% kuri GLP-1 hamwe na aside amine ebyiri gusa hamwe no kongeramo urunigi rwa aside irike.By'umwihariko, lysine iri kumwanya wa 34 yasimbuwe na arginine, naho lysine kumwanya wa 26 yahinduwe hamwe na C16 acyl urunigi binyuze muri glutamoyl.Liraglutide ikura imbaraga zo kurwanya DPP-4 bitewe nuko ikunda gukora micelles no guhuza albumin.Bitandukanye na exenatide yabanjirije iyindi, isaba inshinge ebyiri za buri munsi mbere yo gufungura bwa mbere nanyuma yanyuma yumunsi, liraglutide yemerwa nkuburyo bwo kuvura rimwe kumunsi kandi irashobora gukoreshwa ifatanije na metformin cyangwa sulfonylurea kubarwayi bafite glycemic idahagije hamwe na hamwe monotherapy cyangwa ubuvuzi bubiri.Byemejwe kandi bifatanije nubuvuzi bubiri bwa metformin na thiazolidinedione kubarwayi bafite glycemic idahagije.Liraglutide yerekanye imbaraga zihuza 61 pM (EC50 = 55 pM kuri GLP-1) kubantu bakira GLP-1 yakira.