Ibicuruzwa

Linagliptin Intermediate F, izwi kandi nka 3-aminopiperidine-1-ya karubasi ya acide, ni imiti ikomeye y’imiti muri synthesis ya linagliptin, imiti ikoreshwa mu kuvura diyabete yo mu bwoko bwa 2.Linagliptin ni iy'imiti izwi nka dipeptidyl peptidase-4 (DPP-4) inhibitor, ifasha kugenzura urugero rw'isukari mu maraso.Linagliptin Intermediate F igira uruhare runini mu cyiciro cya nyuma cya synthesis ya linagliptine.Ikora nkibyingenzi byubaka kugirango habeho imiterere yihariye ya chimique ya linagliptin mugukurikirana reaction.Hagati irakoreshwa cyane cyane muguhuza impeta ya piperidine yibanze ya molekulari ya linagliptin.Igihe kimwe, linagliptin ikora muguhagarika ibikorwa byimikorere ya DPP-4.Inzitizi ya DPP-4 ikora mu gukumira isenyuka ry’imisemburo ya incretine, nka glucagon imeze nka peptide-1 (GLP-1), ishinzwe gukurura insuline no guhagarika ururenda rwa glucagon.Muguhagarika DPP-4, linagliptine yongerera imbaraga iyi misemburo ya incretin, biganisha ku kugenzura isukari mu maraso ku bantu barwaye diyabete yo mu bwoko bwa 2.Linagliptine isanzwe itangwa nk'umugereka w'imirire n'imyitozo ngororamubiri mu gucunga diyabete yo mu bwoko bwa 2.Azwiho igice kirekire cyubuzima, butanga inshuro imwe kumunsi.Linagliptin yerekanwe kugabanya neza urugero rwa hemoglobine A1c, ikimenyetso cyo kurwanya glucose igihe kirekire, kandi muri rusange yihanganirwa n’abarwayi.Ikoreshwa rya Linagliptin Intermediate F muri synthesis ya linagliptin ryerekana uruhare rukomeye mu gukora imiti ibyo birashobora kugira ingaruka zikomeye mubuzima bwabantu barwaye diyabete yo mu bwoko bwa 2.Mugutanga umusanzu mukurema imiterere yihariye ya linagliptin, iyi intera ituma ibicuruzwa byanyuma bibuza neza DPP-4 no kunoza igenzura rya glycemic.Mu gusoza, Linagliptin Intermediate F ni uruganda rukomeye rwa chimique muguhuza linagliptin, DPP-4 inhibitor ikoreshwa mu kuvura diyabete yo mu bwoko bwa 2.Uruhare rwayo mu gushiraho imiterere ya molekuline ya linagliptin irashimangira akamaro kayo mu gukora imiti ishobora kunoza isukari mu maraso no kongera imiyoborere ya diyabete.Muguhagarika DPP-4, linagliptine ifasha kugenzura urugero rwa glucose yamaraso kandi ikagira uruhare mubuzima rusange bwabantu barwaye diyabete yo mu bwoko bwa 2.