Ibicuruzwa

Ornithine aspartate niyo yambere yakoreshejwe mubuvuzi mu kuvura hangover na encephalopathie hepatike.Hamwe no gukusanya uburambe bwo gukoresha kwa muganga, ornithine aspartate yakoreshejwe cyane mukuvura indwara zumwijima, kandi imaze kugera ku ngaruka zifatika zo kuvura indwara ya hepatike encephalopathie, kwangirika kwumwijima biterwa n’umwijima, umwijima w’amavuta, hepatite idakira nizindi ndwara, byakwirakwiriye cyane byemewe n'abaganga.

Ornithine aspartate itanga substrate ya urea na glutamine synthesis muri vivo.Glutamine nigicuruzwa cyangiza ammonia, hamwe nuburyo bwo kubika no gutwara amoniya.Mugihe cyimiterere ya physiologique na patologique, synthesis ya urea hamwe na synthesis ya glutamine bigira ingaruka kuri ornithine, acide aspartic nibindi bintu bya dicarboxyl.Ornithine igira uruhare mubikorwa byose byo gukora urea cycle no kwangiza ammonia.Arginine ikorwa muriki gikorwa, hanyuma urea igatandukana kugirango ikore ornithine.Acide ya Aspartic igira uruhare muguhuza aside nucleic muri hepatocytes kugirango byorohereze gusana hepatocytes yangiritse.Byongeye kandi, kubera kuzamura mu buryo butaziguye aside ya aspartique kuri gahunda yo guhinduranya metabolike ya tricarboxylic aside cycle mu ngirangingo z'umwijima, iteza imbaraga imbaraga mu ngirabuzimafatizo z'umwijima, zifasha mu gusana ingirangingo z'umwijima zangiritse kandi byihutisha kugarura imikorere y'umwijima.Iterambere rya vuba ryerekanye ko aspartate ishobora kandi guhagarika ibikorwa bya inflammasomes binyuze muri reseptor ya N-methyl-D-aspartate (NMDA), bityo bikagabanya uburyo bwa farumasi bwo kuvura umwijima.NMDA yakira ni ubwoko bwa ionotropic excitatory glutamate reseptors, bigira uruhare runini mubikorwa bya physiologique nko kwanduza synaptic, plastike synaptic, kwiga no kwibuka muri sisitemu yo hagati.Ubushakashatsi bwakurikiyeho bwanashimangiye ko aspartate yazamuye cyane ibisebe byumwijima.

Gusaba ivuriro

Mu rwego rw'indwara y'umwijima: Ornithine aspartate ikoreshwa cyane nk'umuti urwanya inflammatory na hepatoprotective mu kuvura indwara zitandukanye z'umwijima, nka hepatike encephalopathie, kwangirika kw'umwijima biterwa n'umwijima, umwijima w'amavuta, hepatite idakira, n'ibindi Urwego rwa ammonia yamaraso kubarwayi bafite encephalopathie no kugabanya ibimenyetso byubwonko bwo mu mutwe bigenda bihinduka imiti nyamukuru yo kuvura indwara zitandukanye zumwijima.

Ornithine aspartate ni substrate yingenzi ya synthesis ya urea na glutamine.Ornithine irashobora gukora enzymes zingenzi mugikorwa cya synthesis ya urea - ornithine carbamoyltransferase na carbamoyl phosphate synthase, kandi igateza imbere ammonia Metabolism kugirango igere ku kwangiza ammonia yamaraso, acide aspartic nka substrate irashobora kubyara aside glutamic na aside oxaloacetic, glutamine nigicuruzwa cyangiza. ammonia, kandi nububiko no gutwara amoniya.Oxaloacetate igira uruhare muri cycle ya tricarboxylic, iteza imbere ingufu mu ngirabuzimafatizo z'umwijima, kandi igafasha ingirangingo z'umwijima kwangiritse gusanwa, gushya, no kugarura imikorere y'umwijima.Ornithine aspartate irashobora kunoza neza imikorere yumwijima, kugabanya amoniya yamaraso, no guhuza hamwe kugabanya ammonia hamwe na lactulose na ofloxacin, bityo bikazamura cyane igipimo cyo gukiza indwara ya hepatike encephalopathie, ikwiye gukoreshwa mubuvuzi.

Oncology: Hamwe nimpinduka zikomeje kumoko na dosiye yimiti ya chimiotherapie, ingorane zijyanye nimiti ya chimiotherapie nazo ziragaragara, kandi kwangirika kwumwijima nikimwe mubyangiza umubiri.Umwijima umaze kwangirika, bizagira ingaruka ku buzima bw’umubiri n’ubwenge bw’abarwayi ku buryo butandukanye, bibangamire ishyirwa mu bikorwa rya chimiotherapie, kandi bigabanye ingaruka zo kuvura imiti ya chimiotherapie.Mugihe gikomeye, kunanirwa kwumwijima birashobora guhitana ubuzima.Ornithine aspartate irashobora kunoza cyane kwangirika kwumwijima guterwa nimiti ya chimiotherapie no kunoza uburyo bwo kuvura abarwayi bibyimba.

Umwanya wo kubaga: Kubaga ni ukubabaza ingingo zose z'umubiri w'umurwayi, kandi kwangiza imikorere y'umwijima nyuma yo kubagwa nabyo ni ingorane zisanzwe.Ornithine aspartate irashobora gukumira no kuvura kwangirika kwumwijima nyuma yuburwayi no guteza imbere abarwayi gukira.