L-Glutamine Cas: 56-85-9 99% Ifu yera
| Umubare wa Cataloge | XD90309 |
| izina RY'IGICURUZWA | L-Glutamine |
| URUBANZA | 56-85-9 |
| Inzira ya molekulari | C5H10N2O3 |
| Uburemere bwa molekile | 146.1445 |
| Ibisobanuro birambuye | Ibidukikije |
| Amategeko agenga ibiciro | 29241900 |
Kugaragaza ibicuruzwa
| Ubushyuhe Ububiko | Impamyabumenyi C. |
| Uburemere bwa molekile | 146.14 |
| Suzuma | 99.0% min |
| Kugaragara | Ifu yera |
1.Bambere T-selile precursor leukemia (ETP-BYOSE) ni ubwoko bwubwoko bwinshi bwindwara ya leukemia yabantu itumvikana neza kurwego rwa molekile.Hano twatanze ibisobanuro byibasiye urutoki rwa zinc E-agasanduku-gahuza inyandiko-mvugo ZEB2 nkigisebe gisubirwamo gikomokaho / ETP-BYOSE.Ukoresheje inyungu-yimikorere yimbeba yimbeba, twerekana ko imvugo ya Zeb2 ihamye itangiza T-selile leukemia.Byongeye kandi, Zeb2 itwarwa nimbeba leukemia yerekana ibintu bimwe na bimwe biranga umuntu udakuze / ETP-BYOSE byerekana imvugo ya gene, hamwe nubushobozi bwa leukemia-bwo gutangiza no gukora Janus kinase (JAK) / transducers yerekana ibimenyetso hamwe nabashinzwe kwandukura (STAT) byerekana binyuze gukora transcriptional ya IL7R.Ubu bushakashatsi bugaragaza ZEB2 nka oncogene muri biologiya idakuze / ETP-BYOSE kandi itanga inzira iganisha kubushakashatsi bwambere bwubuvuzi bwibintu bishya kugirango bivure ubu bwoko bwibitero byabantu T-BOSE dukoresheje icyitegererezo cyimbeba ya Zeb2.
2.Ubushobozi, kwiyubaka, no gutandukanya ibintu byihariye biranga ingirabuzimafatizo (ES), bityo bigatanga ibitekerezo byingenzi mubuvuzi bushya.Inzira ziterambere zisaba ishyirahamwe ryateguwe neza, rigengwa cyane cyane na JAK / STAT, PI3K / AKT, na ERK / MAPK inzira.SPREDs (Intungamubiri zijyanye na Sprouty hamwe na domeni ya EVH1) zavumbuwe nkibibuza inzira ya signal ya ERK / MAPK, mugihe ntakintu cyari kizwi kumikorere yabyo muri selile ya ES no mugihe cyo gutandukana hakiri kare, kugeza ubu. Twabyaye SPRED1 na SPRED2 bikabije na SPRED2 knockout murine ES selile zo gusesengura imikorere ya proteine SPRED muri selile ya ES no mugihe cyo gutandukana hakiri kare.Gukabya gukabije kwa SPREDs byiyongera cyane kwiyubaka no gukwirakwiza clonogenicity ya selile ya murine ES, mugihe kubura SPRED2 bigabanya ikwirakwizwa kandi byongera apoptose.Mugihe cyo gutandukanya hakiri kare mumibiri ya emboroid, SPREDs iteza imbere pluripotent kandi ikabuza gutandukana aho mesodermal d ifferentiation mumutima na cardiomyocytes itinda cyane kandi ikabuzwa.UBUZIMA- no gukura ibintu-gukangura byagaragaje ko SPREDs ibuza gukora ERK / MAPK muri selile ya murine ES.Ariko, nta ngaruka zagaragaye kuri LIF iterwa no gukora kwa JAK / STAT3, cyangwa PI3K / AKT inzira yerekana inzira ya proteine za SPRED.Twerekana ko SPRED iteza imbere kwiyubaka no kubuza gutandukanya mesodermal selile ya murine ES mukurwanya guhitamo ERK / MAPK yerekana inzira muri selile pluripotent.
