Ibicuruzwa

Ihuriro rya fer-sulfure ikora nka cofactors ya poroteyine zitandukanye, hamwe ninshingano zinyuranye muri selile ya prokaryotic na eukaryotic.Imashini zabigenewe ziteranya cluster hanyuma ikayigeza kuri molekile yanyuma yakira muburyo bugenzurwa cyane.Muri prototypical Gram-negative bacterium Escherichia coli, sisitemu ebyiri zisanzwe ziteranya ibyuma-sulferi, ibyuma bya sulferi (ISC) hamwe ninzira ya sulfure assimilasiyo (SUF), birahuzwa.Igenzura ryinzira ya ISC, IscR, nimpamvu yo kwandukura ubwoko bwa helix-ihinduka-helix ishobora guhuza cluster ya [2Fe-2S].Imiterere ya Redox hamwe nicyuma cyangwa sulfure iboneka ihindura imiterere yimikorere ya cluster ya IscR ya labile, nayo igena ihinduka ryimiterere ya ADN ikurikirana yihariye: IscR irimo cluster irashobora guhuza umuryango wabateza imbere gene (ubwoko-1) mugihe naho Ifishi idafite cluster imenya itsinda rya kabiri gusa ryurutonde (ubwoko-2).Nyamara, ibyuma bya sulferi biogenezi muri bacteri ya Gram-posi tive ntabwo irangwa neza, kandi ibinyabuzima byinshi byo muri iri tsinda byerekana imwe gusa muri sisitemu yo guteranya ibyuma-sulferi.Ikintu kidasanzwe cyagaragaye ni icyuma cyihariye cya Gram-positifike igabanya bagiteri ya Thermincola potens, aho gen ziva muri sisitemu zombi zishobora kumenyekana, kabone nubwo zaba zifite ishyirahamwe ritandukanya na bagiteri-mbi.Twerekanye ko imwe muriyo genoside ikora IscR homologique ikora kandi birashoboka ko igira uruhare mukugenzura ibyuma-sulfure cluster biogenezi muri T. potens.Imiterere na biohimiki biranga T. potens na E. coli IscR byagaragaje imyubakire isa cyane kandi yerekanaga uburyo butunguranye bwo kubungabunga uburyo budasanzwe bwo kuvangura bikurikirana biranga iri tsinda ryihariye rishinzwe kugenzura inyandiko.