Ibicuruzwa

EAAT2 itwara glutamate, ihwanye na> 90% ya hippocampal glutamate.Nubwo EAAT2 yigaragaza cyane muri astrocytes, ∼10% bya molekile ya EAAT2 iboneka muri axon.Nubwo urwego rwo hasi rwimvugo ya EAAT2 mumagambo ya glutamatergic, mugihe uduce twa hippocampal twibasiwe nubushyuhe buke bwa d-aspartate (substrate ya EAAT2), ama axon akusanya d-aspartate vuba nka astroglia.Ibi bisobanura kudahuza kudasobanutse hagati yo gukwirakwiza poroteyine ya EAAT2 nigikorwa cyo gutwara abantu cya EAAT2.Igitekerezo kimwe ni uko (1) guhindagura ibice byimbere byimbere hamwe na substrate yo hanze byihuta cyane kuruta gufata net kandi (2) ama termine ashyigikira heteroexchange kubera glutamate yimbere.Ariko, kuri ubu ntibiramenyekana niba heteroexchange na uptake bifite ibiciro bisa cyangwa bitandukanye.Kugira ngo iki kibazo gikemuke, twakoresheje sisitemu yongeye gushyirwaho kugirango tugereranye igipimo kigereranyo cyibikorwa byombi mu mbeba n'imbeba.Net uptake yari sen yicaye kumpinduka mubushobozi bwa membrane kandi yashishikarizwaga na anion zinjira hanze zemeranya ko habaho imyitwarire idahwitse.Mugukoresha ibyanyuma, twerekana kandi ko igipimo cya heteroexchange nacyo giterwa na membrane ubushobozi.Byongeye kandi, amakuru yacu arerekana kandi ko muri EAAT2 haboneka sodium.Mugushyiramo ibyashya mubyitegererezo byacu byambere byo gufata glutamate na EAAT2, turahanura ko imbaraga za voltage zo guhanahana amakuru ziterwa na voltage iterwa na gatatu ya Na (+) ihuza.Byongeye kandi, ubushakashatsi bwacu hamwe nibigereranyo byerekana ko igipimo ugereranije cyo gufata net hamwe na heteroexchange bigereranywa muri EAAT2.