Ibicuruzwa

Ivermectin (Cardomec, Eqvalan, Ivomec) ni uruvange rwa 22,23-dihydro ikomoka kuri avermectine B1a na B1b itegurwa na hydrogenation ya catalitiki.Avermectins yibuka umuryango wa antibiyotike igoye yubatswe ikorwa na fermentation hamwe na Streptomycesavermitilis.Ubuvumbuzi bwabo bwaturutse ku kugenzura cyane imico yimiti igabanya ubukana bwa kamere.Ivermectin ikora muri dosiye nkeya irwanya ubwoko butandukanye bwa nematode na arthropods parasitizeanimals.
Ivermectin imaze kugera ku mikorere y’ubuvuzi bw’amatungo muri Amerika ndetse no mu bihugu byinshi ku isi mu rwego rwo kurwanya endoparasite n’inyamaswa zo mu rugo ectoparasite.Byagaragaye ko ari byiza kuvura indwara ya onchocerciasis (“ubuhumyi bw’umugezi”) mu bantu, indwara ikomeye yatewe na volwulusOncocerca volvulus, yiganje muri Afurika y'Iburengerazuba no Hagati, Uburasirazuba bwo hagati, na Amerika y'Amajyepfo na Hagati.Ivermectin isenya microfilariae, idakuze. imiterere ya nematode, ikora uruhu na tissue nodules biranga kwandura kandi bishobora gutera ubuhumyi.Bibuza kandi kurekura microfilariae ninzoka za adadult ziba mubakira.Ubushakashatsi bwakozwe ku mikorere y'ibikorwa bya ivermectin bwerekana ko ibuza kwanduza interneuron - moteri ya neuron muri nematode mu kurekura irekurwa rya neurotransmitter GABA. Uyu muti watanzwe n’uwabikoze ashingiye ku buntu bwa muntu muri gahunda y’ubuvuzi yujuje ibisabwa binyuze mu muryango w’ubuzima ku isi.

Ivermectin ifite ibikorwa byinshi byerekana ko ishobora kugira ingaruka kuri nematode, udukoko, na parasite ya acarine.Numuti wahisemo muri onchocerciasis kandi ni ingirakamaro cyane mukuvura ubundi buryo bwa filariyasi, strongyloidiasis, asikariyasi, loiasis, hamwe na lisansi yimuka.Irakora kandi cyane kurwanya mite zitandukanye.Numuti uhitamo mukuvura abantu banduye Onchocerca volvulus, ikora nkumuti wa microfilaricidal kurwanya liswi ituye uruhu (microfilariya).Kuvura buri mwaka birashobora gukumira ubuhumyi kuri ocular onchocerciasis.Ivermectin biragaragara ko ikora neza kuruta diethylcarbamazine muri bancroftian filariasis, kandi igabanya microfilaremia kugera kurwego rwa zeru.Muri brugian filariasis diethylcarbamazine- iterwa na clearance irashobora kuba hejuru.Irakoreshwa kandi mukuvura ibibyimba byimuka no gukwirakwiza strongyloidiasis.Gukoresha neza kwayo gutwita ntabwo byashyizweho neza.