Ibicuruzwa

BBS4 ni imwe muri poroteyine nyinshi zifite inenge zitera syndrome ya Bardet-Biedl (BBS), indwara ya sisitemu nyinshi, ikagaragaza umubyibuho ukabije.BBS4 polymorphism yagiye ifitanye isano n'umubyibuho ukabije udasanzwe wa syndromic.BBS4 umubyibuho ukabije wa molekulike, n'uruhare rwa gene ya BBS4 mugutandukanya adipocyte n'imikorere ntabwo bizwi rwose.Ubu twerekana ko Bbs4 igira uruhare rutaziguye kandi rwingenzi mugukwirakwiza na adipogenezesi: gucecekesha Bbs4 muri 3T3F442A preadipocytes yateje amacakubiri yihuse no gutandukanya aberrant, bigaragarira mubushakashatsi bwakozwe na morphologique (urumuri, gusikana no kwanduza microscopi electronique), gusesengura metabolike (gukusanya amavuta, umwirondoro wa acide na lipolysis) hamwe na marike ya adipogenic (Cebpα, Pparγ, aP2, ADRP, Perilipin).Muri adipogenezi yose kandi iyo ihuye nuburemere bwibinure, selile ya Bbs4 icecekesha irundanya cyane triglyceride kuruta kugenzura adipocytes, nubwo mubitonyanga bito (nyamara binini cyane mubitigiri) birimo imyirondoro ya acide yahinduwe.Kubwibyo, ibinure byinshi mu ngirabuzimafatizo zacecetse ni ingaruka z’igipimo cyinshi cyo gukwirakwizwa kwa adipocyte ndetse no gutandukanya aberrant biganisha ku kwiyongera kwinshi kwamavuta kuri selile.Ibyavuye mu bushakashatsi byerekana ko umubyibuho ukabije wa BBS ushobora guterwa ahanini n’uruhare rutaziguye rwa BBS4 mu buryo bwa physiologique na patrophysiologique bushingiye ku miterere ya tipusi ya adipose ijyanye n'umubyibuho ukabije.