Ibicuruzwa

Heparin, umunyu wa Sodium ni polymer ya heparin itanga ingaruka zikomeye za anticoagulant mukoresha antithrombine.Uku gukora gutera impinduka zifatika muri ATIII kandi zituma habaho guhinduka muburyo bwurubuga rudasanzwe.Heparin ni glycosaminoglycan ya sulfate nyinshi izwiho gukumira ibibyimba.Heparin, Umunyu wa Sodium nawo ukora ibikorwa bya RyR na ATIII.

Imiterere yumubiri nubumashini: sodium ya Heparin ni umweru cyangwa ifu yera hafi, impumuro nziza, hygroscopique, gushonga mumazi, kudashonga mumashanyarazi nka Ethanol na acetone.Ifite umuriro mubi mubisubizo byamazi kandi irashobora guhuza hamwe na cations kugirango ikore molekile.Ibisubizo byamazi birahamye kuri pH 7.

Anticoagulant: Sodium ya Heparin ni anticoagulant, mucopolysaccharide, umunyu wa sodium wa glucosamine sulfate yakuwe mu mucyo wo mu mara w'ingurube, inka n'intama, kandi bigasohorwa na selile ya mast mu mubiri w'umuntu.Kandi mubisanzwe bibaho mumaraso.Sodium ya Heparin ifite imirimo yo gukumira ikwirakwizwa rya platine no kurimbuka, ikabuza ihinduka rya fibrinogen muri fibrin monomer, ikabuza gukora tromboplastine no kurwanya tromboplastine, ikarinda ihinduka rya prothrombine muri trombine na antithrombine.Sodium ya Heparin irashobora gutinza cyangwa kurinda amaraso haba muri vitro ndetse no muri vivo.Uburyo bwibikorwa byabwo biragoye cyane kandi bigira ingaruka kumahuriro menshi mugikorwa cya coagulation.Imikorere yacyo ni: ①buza imiterere n'imikorere ya tromboplastine, bityo bikabuza prothrombine kuba trombine;②ku kwibanda cyane, bifite ingaruka zo guhagarika trombine nizindi mpamvu ziterwa na coagulation, bikabuza fibrinogen kuba Protein ya fibrin;③ irashobora gukumira kwegeranya no gusenya platine.Byongeye kandi, anticoagulant ya sodium ya heparin iracyafitanye isano na sulfate ikabije ya molekile ya molekile yayo.Ibintu bya alkaline byuzuye neza nka protamine cyangwa ubururu bwa toluidine birashobora guhindura imyuka mibi yabyo, bityo birashobora kubuza anticoagulation.Ingaruka.Kuberako heparin irashobora gukora no kurekura lipoprotein lipase muri vivo, hydrolyze triglyceride na lipoprotein nkeya ya chylomicrons, bityo ikagira n'ingaruka za hypolipidemic.Sodium ya Heparin irashobora gukoreshwa mu kuvura indwara ikaze ya tromboembolique, ikwirakwiza imitsi y'amaraso (DIC).Mu myaka yashize, heparin byagaragaye ko ifite ingaruka zo gukuraho lipide yamaraso.Gutera imitsi cyangwa inshinge zimbitse (cyangwa inshinge zo munsi), 5.000 kugeza 10,000.Sodium ya Heparin ntabwo ifite uburozi kandi guhita biva amaraso ni byo byago byingenzi byo kunywa cyane heparin.Bidafite akamaro mu kanwa, bigomba gutangwa no gutera inshinge.Gutera inshinge cyangwa gutera inshinge zirakaze cyane, rimwe na rimwe ingaruka ziterwa na allergique, ndetse no kunywa birenze urugero bishobora no gutera umutima;rimwe na rimwe guta umusatsi byigihe gito no gucibwamo.Byongeye kandi, irashobora gutera kuvunika bidatinze.Gukoresha igihe kirekire birashobora rimwe na rimwe gutera trombose, bishobora kuba ingaruka zo kugabanuka kwa anticoagulase-III.Sodium ya Heparin yandujwe ku barwayi bafite ikibazo cyo kuva amaraso, umwijima ukabije no kubura impyiko, hypertension ikabije, hemophilia, kuva amaraso ava mu nda, ibisebe bya peptike, abagore batwite na nyuma yo kubyara, ibibyimba byo mu nda, ihahamuka no kubagwa.

Gukoresha: Ubushakashatsi bwibinyabuzima, bukoreshwa mukurinda ihinduka rya prothrombine muri trombine, hamwe na antithrombotic.

Imikoreshereze: sodium ya Heparin ni mutopolysaccharide imiti ya biohimiki ikurwa muri mucosa yo mu mara yo mu mara hamwe nibikorwa bikomeye bya anticoagulant.Mclcan yavumbuye imbwa ya mucopolysaccharide heparin mu ngingo z'umwijima ziva mu mbwa igihe yiga uburyo bwo gutembera kw'amaraso.Brinkous n'abandi.yerekanye ko heparin ifite ibikorwa birwanya anticoagulant.Nyuma ya heparin ikoreshwa nka anticoagulant mugukoresha amavuriro kunshuro yambere, yitabiriwe nabantu kwisi yose.Nubwo ifite amateka yimyaka irenga 60 ikoreshwa mumavuriro, nta bicuruzwa bishobora kuyisimbuza rwose kugeza ubu, bityo iracyari imwe mumiti ikomeye ya anticagulant na antithrombotic biochemical.Ifite uburyo butandukanye bwo gukoresha mubuvuzi.Ikoreshwa mu kuvura indwara ya myocardial infarction na hepatite itera indwara.Irashobora gukoreshwa ifatanije na aside ya ribonucleic kugirango yongere imbaraga za hepatite B. Irashobora gukoreshwa ifatanije na chimiotherapie kugirango birinde trombose.Irashobora kugabanya lipide yamaraso no kunoza imikorere yumubiri wabantu.nayo ifite ingaruka runaka.Uburemere buke bwa heparin sodium ifite anticoagulant factor Xa ibikorwa.Ubushakashatsi bwa Pharmacodynamic bwerekanye ko uburemere buke bwa molekuline ya heparin sodium igira ingaruka mbi ku mikorere ya trombus na trombose ya arteriovenous trombose muri vivo no muri vitro, ariko ikagira ingaruka nke kuri coagulation na fibrinolysis, bikavamo ingaruka za antithrombotic.kuva amaraso ntibishoboka.Heparin idakuweho ni uruvange rwa amin glucan glycoside itandukanye ishobora gutinda cyangwa gukumira amaraso haba muri vitro ndetse no muri vivo.Uburyo bwayo bwo kurwanya anticagulation buragoye, kandi bugira ingaruka mubice byose bya coagulation.Harimo kubuza prothrombine muri trombine;kubuza ibikorwa bya trombine;kubuza ihinduka rya fibrinogen muri fibrin;irinde gukusanya platine no kurimbuka.Heparin irashobora kugabanya lipide yamaraso, kugabanya LDL na VLDL, kongera HDL, guhindura ubwonko bwamaraso, kurinda ingirabuzimafatizo ya endoteliyale, kurinda aterosklerose, guteza imbere amaraso, no kunoza imitsi yimitsi.

Gukoresha: Ubushakashatsi bwibinyabuzima, kugirango wirinde guhinduranya prothrombine muri trombine.

Gukoresha: Byakoreshejwe gutinda no gukumira amaraso