Ibicuruzwa

Ibigereranyo byinshi bya guanosine, ni ukuvuga acyclovir (hamwe na prodrug yo mu kanwa prodrug valaciclovir), penciclovir (muburyo bwa prodrug yo mu kanwa, famciclovir) na ganciclovir, bikoreshwa cyane mu kuvura herpesvirus [ni ukuvuga virusi ya herpes simplex virusi 1 (HSV-1), n'ubwoko 2 (HSV-2), virusi ya varicella-zoster (VZV) na / cyangwa abantu cytomegalovirus (HCMV)].Mu myaka yashize, hashyizweho ibigereranyo byinshi bya guanosine, harimo 3 bikomoka kuri cyclopropylmethyl na -methenyl (A-5021 na synguanol) hamwe n’ibikomoka kuri D- na L-cyclohexenyl.Igikorwa cyo kugereranya acyclic / carbocyclic guanosine cyagenwe kurwanya virusi zitandukanye, harimo HSV-1, HSV-2, VZV, HCMV, ndetse na herpesvirus yubwoko bwa 6 (HHV-6), ubwoko 7 (HHV- 7) andika 8 (HHV-8), na virusi ya hepatite B (HBV).Ibigereranyo bishya bya guanosine (ni ukuvuga A-5021 na D- na L-cyclohexenyl G) byagaragaye ko bifite uruhare runini mu kurwanya izo virusi (HSV-1, HSV-2, VZV) zikubiyemo kodegisi yihariye ya Tymidine (TK), byerekana ko ibikorwa byabo bya virusi (byibuze igice) biterwa na fosifora na TK iterwa na virusi.Ibikorwa bya virusi byagaragaye kandi na A-5021 kurwanya HHV-6 hamwe na D- na L-cyclohexenyl G kurwanya HCMV na HBV.Igikorwa cya virusi yibigereranyo bya acyclic / carbocyclic nucleoside byagereranywa cyane na acide mycophenolique, ikumira cyane inosine 5'-monophosphate (IMP) dehydrogenase.Ibigereranyo bishya bya karbocyclic guanosine (ni ukuvuga A-5021 na D- na L-cyclohexenyl G) bitanga amasezerano akomeye, ntabwo ari imiti igabanya ubukana bwa virusi ya herpesvirus gusa, ahubwo inagira imiti igabanya ubukana bwa kanseri hamwe na chimiotherapie ya kanseri, hashingiwe ko (igice cy) selile yibibyimba yandujwe na virusi ya virusi (HSV-1, VZV) TK.