Furazolidone Cas: 67-45-8
| Umubare wa Cataloge | XD91885 |
| izina RY'IGICURUZWA | Furazolidone |
| URUBANZA | 67-45-8 |
| Imiterere ya molekularila | C8H7N3O5 |
| Uburemere bwa molekile | 225.16 |
| Ibisobanuro birambuye | Ibidukikije |
| Amategeko agenga ibiciro | 29349990 |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu y'umuhondo |
| Assay | 99% min |
| Ingingo yo gushonga | 254-256 ° C (Ukuboza) |
| Ingingo yo guteka | 366.66 ° C (igereranya) |
| ubucucike | 1.5406 (igereranya) |
| indangagaciro | 1.7180 (igereranya) |
| Fp | 2 ° C. |
| gukemura | acide formic: soluble50mg / mL |
| pka | -1.98 ± 0,20 (Byahanuwe) |
| Yumva | Umucyo |
| xmax | 365nm (DMSO) (lit.) |
| Igihagararo | Ihamye.Yaka.Ntibishobora gukoreshwa na okiside ikomeye. |
Antibacterial spektr ya furazolidone isa n'iya furazolidone.Nkumuti urwanya kwandura, ufite akamaro mukuvura Salmonella, Shigella, Escherichia coli, Proteus, Streptococcus, na Staphylococcus aureus.Indwara ya bagiteri ntabwo yoroshye guteza imbere ibiyobyabwenge.Ntishobora kandi kwambukiranya antibiyotike yo mu cyiciro cya sulfa.Ikoreshwa cyane mubuvuzi bwa dysentery, enteritis, tifoyide, paratyphoide no kuvura indwara ya trichomoniasis yo mu gitsina.
2. Igicuruzwa ni fungiside ifite spiba yagutse ya antibacterial.Nkumuti urwanya kwandura, ni ingirakamaro mu kuvura bagiteri zitandukanye za Gram-nziza kandi mbi zirimo Escherichia coli, antacracis ya Bacillus, na bacili ya Paratyphoid.Ntabwo ikora neza mukuvura dysentery, enteritis, ahubwo ikoreshwa no kuvura indwara zandurira mu nda ibyara.Mu myaka yashize, ifite ingaruka nziza zo kuvura umuriro wa tifoyide.Nka nyongeramusaruro yibiyobyabwenge ninyamanswa, igira ingaruka zidasanzwe za antibacterial kuri Salmonella, Escherichia coli na Salmonella pullorum kandi ikagira n'ingaruka zimwe na zimwe zo kubuza protozoa (bacteri za coccidia, nibindi) kandi zikaba zidakunda guhinduka mukurwanya ibiyobyabwenge.Umubare muto wa furazolidone wakoreshejwe mubindi bikorwa (nk'irangi ry'amazi ashonga hamwe n'impapuro) nka fungicide.
3. Numuti urwanya kwandura ukoreshwa mukurwanya kwandura amara.
4. Furazolidone, nka fungiside, ifite antibacterial yagutse.Indwara ya bagiteri ikunze kwibasirwa cyane ni Escherichia coli, antacracis ya Bacillus, inkoni ya paratyphoide, Shigella, na Klebsiella pneumoniae.Salmonella typhi nayo irabyumva.Ikoreshwa cyane cyane mu kuvura indwara ziterwa na dysentery, enteritis, na kolera.Irashobora kandi gukoreshwa mu kuvura tifoyide, paratyphoide, giardiasis, na trichomoniasis.Kwivanga hamwe nibiyobyabwenge birwanya aside birashobora gukoreshwa mukuvura Helicobacter pylori-iterwa na gastric inflammation.Ibyiza: ifu yumuhondo cyangwa ifu ya kristaline, impumuro nziza, ubanza uburyohe hanyuma ugahinduka umujinya muke;gushonga gato cyane mumazi na Ethanol;gushonga gake muri chloroform no kudashonga muri ether, gushonga muri dimethylformamide na nitromethane.Mp: 255 kugeza 259 ° C.Kubora mugihe cyo guseswa.
Furazolidone ikoreshwa mu kwandura gastrointestinal na vaginitis.Ikoreshwa cyane cyane mubihugu bikiri mu nzira y'amajyambere kuvura indwara zimpiswi ziterwa na etiologiya zitandukanye, ariko ntabwo ariwo muti wo guhitamo niba hamenyekanye indwara runaka.Koresha nk'umurongo wa kabiri muri giardiasis kandi mubice bya multidrug muri infashanyo ya Helicobacter yarashyigikiwe.
3 - [.Igikorwa cya Furazolidone hasbactericidal kurwanya intera nini cyane yo munda, harimo S. aureus, E. coli, Salmonella, Shigella, Proteus spp., Enterobacter, na Vibrio kolera.Birakora kandi kurwanya protozoan Giardia lamblia.Birasabwa kuvura umunwa kuvura bagiteri cyangwa protozoaldiarrhea iterwa nibinyabuzima byoroshye.Igipimo cya usualadult ni 100 mg inshuro 4 kumunsi.
Gusa agace gato ka dose yatanzwe kumanwa ya furazolidoneis yakiriwe.Hafi ya 5% yumuti wumunwa ntushobora kumenyekana muminkari muburyo bwa metabolite nyinshi. Bimwe mubibazo byo munda byavuzwe ko byakoreshejwe. Inzoga zigomba kwirindwa mugihe furazolidone ikoreshwa kubera ko imiti ishobora kubuza aldehyde dehydrogenase.
