Ibicuruzwa

Islet amyloide polypeptide (IAPP; izwi kandi nka amylin) ishinzwe gushinga amyloide ya islet muri diyabete yo mu bwoko bwa 2, kandi uburozi buterwa na IAPP bwizera ko bugira uruhare mu gutakaza imbaga ya selile ifitanye isano na nyuma ya diyabete yo mu bwoko bwa 2.Imiterere ya Islet amyloide irashobora kandi kugira uruhare mukunanirwa kwangirika nyuma yo guhindurwa.IAPP ikorwa nka prohormone, pro-islet amyloid polypeptide (proIAPP), kandi igatunganyirizwa muri granules yibanga ya pancreatic β-selile.Uburyo butunganijwe bwa proIAPP buboneka mububiko bwa amyloide;icyamenyekanye cyane ni 48-isigaye hagati, proIAPP (1-48), ikubiyemo N-terminal pro-kwagura, ariko yatunganijwe neza kuri C-terminus.Gutunganya bituzuye birashobora kugira uruhare mugushinga amyloide islet mugutezimbere imikoranire na proteoglycans ya sulfate ya matrice idasanzwe, nayo igateza imbere amyloide.Twerekana ko aside fuchsin (3- (1- (4-amino-3-methyl-5-sulphonatophenyl) -1- (4-amino-3-sulphonatophenyl) methylene) cyclohexa-1,4-dienesulphonic aside), byoroshye sulfonated triphenyl methyl ikomoka, ni inhibitor ikomeye yo gushiraho amyloide na proIAPP (1-48) hagati.Kurusha cyane triphenyl methane ikomokaho byihuse icyatsi FCF {ethyl- [4 - [[4- [ethyl - -2,5-dienylidene] -Ibyo bikoresho byombi bibuza amyloide kuvangwa nuruvange rwa proIAPP rwagati hamwe nicyitegererezo glycosaminoglycan heparan sulfate.Acide fuchsin irabuza kandi glycosaminoglycan-yunganirwa na amyloide yakozwe na IAPP ikuze.Ubushobozi bwo guhagarika amyloide ntabwo buterwa gusa nuburinganire bwa sulfonone, kubera ko sulfonated inhibitor ya amyloide-β, tramiprosate, ntabwo ari inzitizi yo gushiraho amyloide na proIAPP (1-48).