Ibicuruzwa

Flucytosine, izwi kandi ku izina rya 5-fluorocytosine cyangwa 5-FC, ni imiti igabanya ubukana ikoreshwa cyane mu kuvura indwara zanduza.Yashyizwe mubikorwa nka antimetabolite, bivuze ko ibangamira imikorere isanzwe ya metabolike yingirabuzimafatizo, ibabuza cyangwa gupfa.Ubusanzwe Flucytosine itangwa ifatanije nindi miti igabanya ubukana kugira ngo ikore neza. Kimwe mu bintu by'ingenzi bikoreshwa na flucytosine ni mu kuvura indwara ziterwa na fungal, cyane cyane izatewe n'ubwoko bwa Candida na Cryptococcus.Ikunze gukoreshwa ifatanije nindi miti igabanya ubukana, nka amphotericine B cyangwa fluconazole, kugirango yongere ibikorwa byayo.Flucytosine ikora yinjira mu ngirabuzimafatizo kandi igahinduka 5-fluorouracil, antimetabolite ya cytotoxic.5-fluorouracil noneho ibangamira synthesis ya RNA na ADN ya fungal, bityo bikabuza gukura kwimyanya no kwigana.Ubu buryo bwo guhuza imbaraga bufasha kurwanya indwara nyinshi ziterwa na fungal no kongera uburyo bwo kuvura.Ubundi buryo bukomeye bwo gukoresha flucytosine ni mu kuvura Cryptococcus neoformans meningitis, indwara ishobora guhitana ubuzima yibasira imitsi ikikije ubwonko n’umugongo.Flucytosine ifatwa nk'imwe mu miti ya mbere ivura ifatanije na amphotericine B yo kuvura iki kibazo.Ubuvuzi bukomatanya bufasha gutsinda imipaka ya buri muti wonyine no kugera ku kigero cyo hejuru cyo gukira.Flucytosine igera ku kigero gihagije mu mazi yo mu bwonko, ikayifasha kwibasira neza kwandura ibihumyo muri sisitemu yo hagati yo hagati.Flucytosine irashobora kandi gukoreshwa mu kuvura izindi ndwara zifata ibihumyo, nk'indwara ziterwa n'ubwoko bumwe na bumwe bwa Candida na Aspergillus.Ariko, imikoreshereze yacyo irashobora kuba mike kubera ibyago byo kurwanywa, kuko igihumyo gishobora kubona ihinduka ryimiterere ituma bidashoboka kwanduza ibiyobyabwenge.Gukurikiranira hafi no gusuzuma buri gihe ibisubizo byubuvuzi nibyingenzi mugihe ukoresheje flucytosine kugirango harebwe ibisubizo bikwiye byo kuvura.Nubwo ubusanzwe flucytosine yihanganira neza, irashobora kugira ingaruka mbi.Ingaruka zikunze kugaragara zirimo guhungabana gastrointestinal, nko kugira isesemi, kuruka, no gucibwamo.Irashobora kandi gutera igufwa ryamagufa, bishobora gutuma umusaruro wamaraso ugabanuka.Isuzuma ryamaraso risanzwe rikorwa kenshi kugirango harebwe umubare wamaraso mugihe cyo kuvura.Mu ncamake, flucytosine ni imiti igabanya ubukana ikoreshwa mukuvura imiti yanduye, cyane cyane iyatewe nubwoko bwa Candida na Cryptococcus.Ikora ibangamira synthesis ya fungal nucleic aside, ikabuza gukura no kwigana.Flucytosine ikunze gukoreshwa ifatanije nindi miti igabanya ubukana kandi ni ingenzi cyane mu kuvura Cryptococcus neoformans meningitis.Ariko, imikoreshereze yacyo isaba gukurikiranwa neza bitewe ningaruka zo guhangana ningaruka mbi.