Ibicuruzwa

Indwara ya karande ihumeka no kuvugurura, harimo na fibrosis, byasabwe nkabagize uruhare runini muri asima pathophysiology.Ubushakashatsi bwibanze kuri fibrosis yo mu kirere bwakozwe cyane cyane muri asima yoroheje kandi yoroheje kurwego rwa subepithelial "basement membrane" (SBM).Ubu bushakashatsi bwakozwe hagamijwe gusuzuma ubunini bunini bwo mu kirere SBM hamwe n’ububiko bwa subucosal collagen, nkuko byapimwe nuburyo butatu butandukanye bwo gusiga irangi, muri biopies ya endobronchial kuva 17 bikabije, icyenda giciriritse, na karindwi byoroheje byoroheje, hamwe n’ibintu umunani bisanzwe bigenzura.Hakozwe kandi isuzuma rya eosinofile ya tissue no guhindura ibintu bikura-beta (TGF-beta) immunoreactivite.Nta tandukanyirizo rishingiye ku mibare ryari rifite mu bunini bwa SBM, mu bubiko bwa subucosal collagen, imibare ya eosinofil, cyangwa selile nziza ya TGF-beta mu matsinda atatu ya asima hamwe n’ibisanzwe bigenzura.Igihe twasuzumaga asima yose (n = 33) hamwe, ni bwo SBM yabyimbye mu buryo bworoheje (p = 0.04), nkuko byasuzumwe n’ubudahangarwa bwo mu bwoko bwa III bwa kolagen, byagaragaye ugereranije n’ibisanzwe bigenzurwa.Nubwo iri tandukaniro, nta tandukaniro rikomeye ryabonetse mubunini bwa subucosal collagen yoherejwe n'umubare wa eosinofile cyangwa TGF-beta yerekana selile iyo ugereranije asima yose hamwe nibisanzwe bigenzura.Byongeye kandi, nta sano ihambaye yabonetse hagati yo kubika kolagen no kubara eosinofil, urwego rwa TGF-beta imvugo, FEV1, cyangwa igihe cya asima.Ibisubizo byerekana ko nubwo kwiyongera kwa kolagen muri SBM kurwego runini rwumuyaga biranga asima, ntibishobora gusobanura itandukaniro ryuburemere bwa asima.