Doxifluridine Cas: 3094-09-5
| Umubare wa Cataloge | XD90592 |
| izina RY'IGICURUZWA | Doxifluridine |
| URUBANZA | 3094-09-5 |
| Inzira ya molekulari | C9H11FN2O5 |
| Uburemere bwa molekile | 246.20 |
| Ibisobanuro birambuye | 2 kugeza 8 ° C. |
| Amategeko agenga ibiciro | 29349990 |
Kugaragaza ibicuruzwa
| Kugaragara | Umweru wo kuzimya ifu ya kirisiti |
| Suzuma | ≥99% |
| Ingingo yo gushonga | 189 - 193 ° C. |
Imiti ya Fluorouracil antineoplastique ni prodrugs ya fluorouracil.Thymidine phosphorylase iri muri tissue yibibyimba irayikora kugirango ihindure fluorochemicalbook uracil mu kibyimba, bityo igire ingaruka zo kurwanya ibibyimba.Umwihariko wacyo wo kurwanya ibibyimba urakomeye, kandi uburozi bwabwo buri hasi.Ivuriro rikoreshwa muri kanseri yo mu gifu, kanseri yibara, kanseri y'ibere, igipimo cyo kwandura gishobora kugera kuri 30%.
Ingaruka za chimiotherapie sisitemu yo gukwirakwiza kanseri yo mu gifu ntisobanutse neza.Hakozwe isuzumabushobozi rya paclitaxel ya buri cyumweru ifatanije na doxifluridine (5'-DFUR) ku barwayi ba kanseri yo mu gifu bafite indwara ya asitike mbi.Ubuvuzi bwari bugizwe na paclitaxel imitsi (iv) itangwa kuri 80 mg / m (2) kumunsi wa 1, 8 na 15 buri byumweru 4, naho doxifluridine itangwa kumanwa kuri 533 mg / m (2) kumunsi 1-5 buri cyumweru.Igipimo cyo gusubiza abarwayi bafite asite cyagenwe hashingiwe ku kiyapani cyo mu bwoko bwa Gastric Carcinoma.Nanone, hapimwe ubunini bwa paclitaxel muri asite. Hakozwe iperereza ku barwayi makumyabiri na bane.Igipimo cy’ibisubizo (RR) cyari 41.7%, harimo gukira burundu (CR) no kuvura igice (PR) ku barwayi 4 na 6.Ubwinshi bwa paclitaxel muri asike bwagumishijwe hagati ya 0.01 μM na 0.05 μM kugeza amasaha 72.Hagati yo kubaho muri rusange (OS) yari iminsi 215, naho imyaka 1 yo kubaho yari 29.2%.Nta burozi bukabije bwagaragaye.Weekly paclitaxel ifatanije na doxifluridine ni ingirakamaro ku barwayi ba kanseri yo mu gifu bafite asitike mbi kandi ifite uburozi bwemewe.
