Ibicuruzwa

Imitsi irenze urugero igira uruhare mu kurwara.Uburyo bugezweho bwo gusuzuma vivo kwisuzumisha hashingiwe ku gukabya kwa Evans Ubururu (EB) -ububiko bwa alubumu iragoye kandi akenshi ibura sensibilité.Twateje imbere uburyo bushya bwa infragre fluorescence (IRF) uburyo bwo gupima ibicuruzwa bya EB-albumin kugirango tugereranye imiyoboro y'amaraso muri moderi ya murine.Imiyoboro y'amaraso iterwa na endotoxaemia yasuzumwe ingingo zose zikomeye, ubwonko, uruhu na peritoneum na IRF hamwe no gupima gakondo gushingiye kuri EB mu gukuramo ibice.Urwego IRF rwiyongereye kumurongo hamwe no kwiyongera kwa EB imitsi (2,5-25 mg / kg).Tissue IRF yariyunvikana cyane gukusanya EB ugereranije nuburyo bushingiye ku kwinjiza.Kubera iyo mpamvu, itandukaniro ryimitsi iva mumitsi hamwe no kwegeranya kwa EB hagati yimbeba zavuwe na lipopolysaccharide nimbeba zivuwe na saline akenshi zari ingirakamaro mugihe wasesenguwe nubushakashatsi bwakozwe na IRF ariko ntibukorwe nubushakashatsi bushingiye ku kwinjiza.EB yagaragaye mu ngingo zose uko ari 353 zasesenguwe na IRF ariko muri 67% gusa (239/353) zingingo zasesenguwe hakoreshejwe uburyo bushingiye ku kwinjiza ibintu, byerekana uburyo bunoze bwo kumva neza EB mu ngingo zifite IRF.Ibinyuranye, EB muri plasma nyuma yubuyobozi bwa EB yapimwe byoroshye nuburyo bwombi bufitanye isano ryinshi hagati yuburyo bubiri (n = 116, r2 = 0.86).Umubare wibice byihariye bya EB-IRF bitewe na endotoxine byari byiza mugihe IRF yagereranijwe hagati yimbeba zihuye nuburemere, igitsina, n'imyaka, hamwe no gukosora bikwiye kuburemere bwingingo hamwe na EB plasma yibanze.Ikigaragara ni uko uburyo bwa EB-IRF busiga ingingo zidahwitse kuri histopathology ikurikira.Muri make, EB-IRF ni igitabo gishya, cyunvikana cyane, cyihuse, kandi cyoroshye kuburyo bugereranije bwa EB mubice bidafite ubuvuzi hamwe nimbeba zo kugenzura.