DAPI (4,6-Diamidino-2-fenylindole dihydrochloride) CAS: 28718-90-3 99% Ifu yumuhondo
| Umubare wa Cataloge | XD90505 |
| izina RY'IGICURUZWA | DAPI (4,6-Diamidino-2-fenylindole dihydrochloride) |
| URUBANZA | 28718-90-3 |
| Inzira ya molekulari | C16H15N5 · 2HCl |
| Uburemere bwa molekile | 350.25 |
| Ibisobanuro birambuye | Ibidukikije |
| Amategeko agenga ibiciro | 2933998090 |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu y'umuhondo |
| Suzuma | 99% min |
| Kubushakashatsi ukoreshe gusa, ntabwo ari ugukoresha abantu | Gukoresha ubushakashatsi gusa, ntabwo ari ugukoresha abantu |
Melatonin igira uruhare mu mikorere myinshi ya physiologiya, kandi igira ingaruka zitandukanye kuri apoptose mungirangingo zisanzwe na kanseri.Nyamara, uburyo bwinshingano za antitumor ntabwo bwumvikana neza.Muri ubu bushakashatsi, twerekana ko melatonine yongerera tunicamycin iterwa na apoptose muri kanseri y'ibere ya muntu MDA-MB-231.Melatonin igenzura-poroteyine ya poroteyine Bim imvugo Bim kurwego rwo kwandukura imbere ya tunicamycin.Melatonin ibuza imvugo ya tunicamycin iterwa na COX-2 muri selile MDA-MB-231.Byongeye kandi, kubuza ibikorwa bya COX-2 ukoresheje COX-2 inhibitor, NS398, byongera apoptose ya tunicamycine.Igishimishije, izi ngaruka ntabwo zajyanye na melatonin reseptor signal inzira.Uburozi bwa Pertussis (inhibitor ya Gi protein rusange) cyangwa luzindole (antagonist ya melatonin idasanzwe) ntabwo byahinduye ingaruka za melatonine.Byongeye kandi, melatonin yahagaritse tunicamycin iterwa na NF-κB ibikorwa byo kwandikirana, p65 ihinduranya kirimbuzi, na p38 MAPK ikora ivation.Melatonin-yunganirwa na p38 MAPK kubuza byagize uruhare mu kugabanuka kwa COX-2 mRNA.Dufatiye hamwe, ibisubizo byacu byerekana ko melatonin yongera imikorere ya antitumor binyuze mu kugenzura imvugo ya Bim no kugabanya imvugo ya COX-2 mu ngirabuzimafatizo ya MDA-MB-231.
