Ibicuruzwa

Filime ya Mucoadhesive irimo nanoparticles yuzuye curcumin yuzuye, igamije kongera igihe cyo gutura kumiterere ya dosiye mumyanya yo mu kanwa no kongera ibiyobyabwenge binyuze mumitsi ya buccal.Filime zateguwe nuburyo bwo gukina nyuma yo kwinjizwamo curcumin yuzuye chitosan yuzuye polycaprolactone nanoparticles mubisubizo bya chitosani.Imyanda itandukanye ya mucoadhesive polysaccharide chitosan hamwe nubushuhe bwa plasitike glycerol yakoreshejwe kugirango hitegurwe neza.Filime zabonetse hakoreshejwe chitosan yo hagati na nini ya molarike wasangaga bahuje ibitsina kandi byoroshye.Nanoparticles yuzuye Curcumin yatanzwe ku buso bwa firime, nkuko bigaragazwa na microscopie yingufu za atome hamwe n’ibisasu bihanitse cyane byohereza mu kirere amashusho ya electron microscopi (FEG-SEM).Isesengura ryibice bya firime ukoresheje FEG-SEM byerekana ko hariho nanoparticles imbere muri firime.Byongeye kandi, firime zagaragaje ko zifite umuvuduko mwiza wogukwirakwiza mumacandwe yigana amacandwe, yerekana kubyimba ntarengwa hafi 80% no muri vitro igihe kirekire igenzurwa na curcumin.Ibisubizo byerekana ko firime ya mucoadhesive irimo nanoparticles itanga uburyo butanga ikizere cyo gutanga buccal ya curcumin, ishobora kuba ingirakamaro cyane mukuvura indwara zigihe kirekire zisaba gutanga imiti irambye. © 2014 Wiley Periodicals, Inc. hamwe n’ishyirahamwe ry’aba farumasi muri Amerika.