Ibicuruzwa

Cardioprotectant: Creatine fosifate ni ikintu cyingenzi gitanga ingufu mukugabanya imitsi no guhindagurika.Nibikoresho bya chimique bibika imitsi yoroshye n'imitsi ihindagurika, kandi ikoreshwa kuri ATP resynthesis.Phosphocreatinedisodium nuburyo bwayo bwo kuvura.Sodium Creatine Phosphate, izina ryimiti N- [imino (phosphono) methyl] -N-methylglycine umunyu wa disodium, ni imiti yumutima yatangijwe n’uruganda rwa farumasi rwa Ouhui rwo mu Butaliyani mu 1992. Imiterere ya fosifore ifite uruhare runini rw’umubiri, kandi ikoreshwa cyane kurinda myocardial kubarwayi barwaye ischemia yumutima cyangwa mugihe cyo kubaga umutima wa Chemical Bookbook, no kuvura indwara z'umutima-damura nko kunanirwa k'umutima, infirasiyo ya myocardial na arththmia.Irashobora kunoza imikorere yumutima hamwe nimpinduka zumutima kubarwayi bafite ischemic cardiomyopathie.Ntishobora gutanga ingufu gusa mungirangingo ya myocardial mugihe irwaye ischemia na hypoxia, ariko kandi irinda ururenda rwa myocardial selile kwibasirwa na ogisijeni yubusa ya ogisijeni nibindi bintu byangiza, bishobora kugira ingaruka kumikorere yumutima.Kurinda myocardial nyuma yuburwayi ku barwayi bafite indwara ya valvular idafite ubushobozi ni ingirakamaro mu gukira nyuma yo gukira imikorere yumutima ku barwayi bafite indwara zidafite ubushobozi buke.Kubikoresha kugirango bivure byimazeyo ibyangiritse bya myocardial nyuma ya neonatal asphyxia irashobora kunoza cyane imisemburo ya myocardial na electrocardiogram, kandi ifite ingaruka nziza zo gukiza numutekano.

Ibiranga imikorere Iki gicuruzwa nububiko bwimiti yimitsi yumutima na skeletale, kandi bikoreshwa mugusubirana kwa ATP, bitanga ingufu mugikorwa cyo kugabanuka kwa actomyosine, kandi bigira uruhare runini muburyo bwo guhinduranya imbaraga zo kugabanuka kwimitsi.Ingufu zidahagije ni ikintu cyingenzi mu gushiraho no guteza imbere imvune ya myocardial selile.

1. Ifite ingaruka zikomeye zo kurinda imikorere ya ischemic myocardial systolique, ishobora kugarura byimazeyo no kugabanya umuvuduko wamaraso wa diastolique.

2. Komeza ibikubiye muri adenosine triphosphate na fosifine ya creine mu ngirabuzimafatizo, kandi Chemical Book ikomeza kubika ingufu za myocardial.

3. Kugabanya igihombo cya creine kinase no kugabanya ibyangiritse bya selile.

4. Ifite anti-peroxidation.

5. Kunoza microcirculation myocardial.Bitewe no kuba hariho fosifate zifite ingufu nyinshi muri molekile ya fosifate ya vitamine, imiyoboro ya fosifate ifite ingufu nyinshi irashobora guhindura ADP muri ATP ikozwe na fosifine, kandi igaha imbaraga umubiri kugirango uhite ukora.Nkigicuruzwa giciriritse cya glycolysis, sodium fructose diphosphate ikeneye kugira uruhare rutaziguye binyuze muri anaerobic metabolism.

inzira yubukorikori:

1 Koresha fosifate ya dibenzyl nkibikoresho fatizo, reba hamwe na chloride ya oxalyl kugirango ubone chloride ya dibenzyl oxyphosphoryl,

2 Mubikorwa bya triethylamine, dibenzyloxyphosphoryl creatine ethyl ester yabonetse kubisubizo hamwe na creine Ethyl ester hydrochloride irazunguruka kuri dibenzyloxyphosphoryl creatinine,

3. Nyuma ya karubone ya palladium yatangije hydrogenolysis kuri debenzylate, reba hamwe na hydroxide ya sodium kugirango ubone fosifate ya disodium creatinine,

4 ni hydrolyzed to 1 munsi ya hydroxide ya sodium.

Gukoresha: Birakwiriye kurinda metabolisme idasanzwe ya myocardial muri leta ya ischemia myocardial.

Ingaruka mbi, kwanduza n'ingaruka zibiyobyabwenge: abafite allergie kubigize ibicuruzwa barabujijwe;abafite ikibazo cyo kubura impyiko zidakira barabujijwe gukoresha dosiye nini (5-10g / d).Gutera umuvuduko ukabije wa 1g birashobora gutera umuvuduko wamaraso.Ubuyobozi bukabije butera fosifate nyinshi, ishobora kugira ingaruka kuri calcium metabolisme no gusohora imisemburo igenga homeostasis, bikagira ingaruka kumikorere yimpyiko na metabolism ya purine.