Ibicuruzwa

Ingaruka mbi ningirakamaro mugutanga intege nke zo kurwanya ibiyobyabwenge nkuko bigaragazwa nubwinshi bukabije bwihohoterwa rya opiate hamwe nindwara ikomeye yo kwiheba (MDD).Icyitegererezo cyimbeba cyerekana amygdala prodynorphine (Pdyn) nkumuhuza wingaruka mbi;icyakora, ibimenyetso byerekana uruhare rwa PDYN mubikorwa bibi byabantu ni bike.Hano, twasanze imvugo ya PDYN mRNA yagabanutse muri postmortem yumuntu amygdala nucleus ya cortex ya periamygdaloid (PAC) mubakoresha ibiyobyabwenge bya heroine ndetse na MDD.Kimwe nabantu, imbeba zagiye ziyobora heroine zagabanije imvugo ya Pdyn mRNA muri PAC mugihe kijyanye na leta mbi.Twifashishije tekinoroji ya vivo ikora ya DREAMM (mapping ya DREADD ifashwa na metabolic mapping, aho DREADD yerekana reseptor ya reseptor ikoreshwa gusa nibiyobyabwenge byabashushanyije), twasanze kubuza guhitamo neuron ya Pdyn yerekana imbeba PAC byongereye ibikorwa bya metabolike muri amygdala yagutse. ni urufunguzo rwibanze rwa sisitemu yo guhangayikisha ubwonko bwa extrahypothalamic.Mugihe kimwe, PAC yihariye Pdyn yabujije yateje ingaruka mbi zijyanye na physiologique nimyitwarire.Twese hamwe, ubushakashatsi bwacu bwubuhinduzi bushigikira uruhare rwibikorwa bya Pdyn wangiritse muri PAC mugukoresha nabi nabi binyuze mukugirango uhangayike kandi bigira ingaruka mbi kuri neurocircuitry zigira uruhare mu kwibasirwa n’ibiyobyabwenge.