Ibicuruzwa

Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ni imiti ivanga imiti isanga ikoreshwa mubijyanye na chimie yubuvuzi no guteza imbere ibiyobyabwenge.Imiterere ya molekuline igizwe nimpeta ya pyrrolidine hamwe nitsinda rya tert-butyl kumwanya wa cis, itsinda rya Ethyl, nitsinda rya karubasi ebyiri.Iyi nteruro isanzwe iboneka muburyo bwumunyu wa hydrochloride.Bimwe mubintu byingenzi bikoreshwa cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride iri murwego rwo guhuza no guteza imbere ibiyobyabwenge byibasira hagati. sisitemu y'imitsi (CNS).Kuba impeta ya pyrrolidine, hamwe na tert-butyl na ethyl matsinda, itanga iyi compound hamwe nibishobora kuba biterwa na neuroactive.Abashakashatsi barashobora gukoresha iyi nteruro nkibikoresho byo gutangira kugereranya ibigereranyo cyangwa ibiyikomokaho bishobora guhitamo gukorana na reseptor cyangwa enzymes zihariye muri CNS.Muguhindura imiterere ninsimburangingo, barashobora kunonosora imiti ya farumasi ya farumasi, kongera imbaraga za reseptor, no kunoza ubushobozi bwo kuvura.Ikindi kandi, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride irashobora kuba akoreshwa nkigikoresho cyifashishwa mubushakashatsi bwibinyabuzima kugirango akore iperereza ku ruhare rwakirwa cyangwa imisemburo yihariye mu mitsi.Ukoresheje iyi nteruro nka ligand cyangwa probe, abashakashatsi barashobora kwiga guhuza isano, guhitamo, hamwe nuburyo bwibikorwa byaba reseptors cyangwa enzymes.Aya makuru ni ingenzi cyane mu gusobanukirwa ishingiro ryimikorere ya neurofarmacologique no guteza imbere imiti yubuvuzi yibanda ku ndwara zifata ubwonko, indwara zo mu mutwe, cyangwa indwara zifata ubwonko. Uru ruganda kandi rufite uburyo bushobora gukoreshwa mu kuvumbura ibiyobyabwenge no gusuzuma ibicuruzwa byinshi.Irashobora kwinjizwa mumasomero yibintu, bisuzumwa kubintu bitandukanye, nka reseptor cyangwa enzymes, kugirango hamenyekane ibishobora kuvangwa cyangwa abakandida ibiyobyabwenge.Iri genzura ryemerera kumenya ibice byerekana imiti yifuzwa ya farumasi cyangwa ingaruka zishobora kuvura.Ikindi kandi, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride irashobora kubona akamaro mugutezimbere prodrugs.Prodrugs idakora cyangwa idakora cyane igenewe guhindurwa muburyo bukora rimwe mumubiri.Muguhindura imiterere yuru ruganda, abashakashatsi barashobora gukora imiterere ya prodrug ihamye, itezimbere bioavailable, cyangwa irashobora kwambuka ibinyabuzima byoroshye.Ibi birashobora kongera inyungu zo kuvura no kuvura imiti ya farumasi.Mu ncamake, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ni uruhurirane hamwe nibishobora gukoreshwa mugutezimbere imiti igamije CNS , nkigikoresho cyo guhuza ubushakashatsi bwibinyabuzima, mubuvumbuzi bwibiyobyabwenge, no mugutezimbere prodrugs.Imiterere yihariye ya molekile itanga amahirwe yo guhindura no gutezimbere kugirango yongere imiti ya farumasi nibikorwa byibinyabuzima.Ubwinshi nubushobozi bwuru ruganda bigira umutungo wingenzi mubijyanye na chimie yimiti no guteza imbere ibiyobyabwenge.