Ibicuruzwa

Bromelain (BR) ni protease ya sisitemu ifite ingaruka zo kubuza gusohora amara no gutwika.Nyamara, ingaruka zacyo kumitsi yo mara ntizigaragara.Ni yo mpamvu, twasesenguye ingaruka z’uru ruganda rukomoka ku bimera ku mitsi yo mu nda no gutambuka mu mbeba.Ubusabane muri vitro bwasuzumwe no gukangurira imbeba yitaruye ileum, mu bwogero bw’umubiri, hamwe na acetylcholine, barium chloride, cyangwa amashanyarazi.Imbaraga muri vivo zapimwe mugusuzuma ikwirakwizwa ryikimenyetso cya fluorescente mu kanwa ku mara mato.Transit kandi yasuzumwe muri leta ya pathophysiologique iterwa namavuta ya croton ya pro-inflammatory cyangwa na diabete ya agent ya streptozotocine.Bromelain yabujije kugabanuka kwatewe ningingo zitandukanye za spasmogeneque mumbeba ileum ifite imbaraga zisa.Ingaruka ya antispasmodic yagabanutse cyangwa irwanywa na proteolytic enzyme inhibitor, gabexate (15 × 10 (-6) mol L (-1)), protease ikora r eceptor-2 (PAR-2) antagonist, N (1) -3 -methylbutyryl-N (4) -6-aminohexanoyl-piperazine (10 (-4) mol L (-1)), fosifolipase C (PLC) inhibitor, neomycine (3 × 10 (-3) mol L (-1)) , na fosifodiyesterase 4 (PDE4) inhibitor, rolipram (10 (-6) mol L (-1)).Muri vivo, BR yahisemo guhagarika motifike muri reta ya patrophysiologique muburyo bwa PAR-2-bwanga-antagonist.Imibare yacu yerekana ko BR ibuza umuvuduko wo munda - cyane cyane mubihe bya patrophysiologique - hamwe nuburyo bushobora kuba burimo membrane PAR-2 ​​na PLC na PDE4 nkibisanzwe. ibimenyetso.Bromelain irashobora kuba intandaro yo guteza imbere imiti mishya, ibasha guhindura imikorere y amara mugutwika na diyabete.