Ibicuruzwa

Metabolite yo mu mara ya ginseng protopanaxadiol saponin, 20-O- (β-D-glucopyranosyl) -20 (S) -protopanaxadiol (compound K), byavuzwe ko itera apoptose mu ngirabuzimafatizo zitandukanye za kanseri.Nyamara, uburyo nyabwo bwatewe nuruvange K mu ngirabuzimafatizo ya hepatocellular kanseri (HCC) ntirurasobanuka neza.Kugirango dusuzume uburyo bushoboka bwa apoptotique, twasesenguye ingaruka za anticancer ziterwa na K muri MHCC97-H.Ubushakashatsi bwa MTT bwerekanye ko ifumbire K yabujije ikwirakwizwa rya selile MHCC97-H ifite uburozi buke ugereranije na selile isanzwe ya hepatoma.Iterambere ry'utugingo ngengabuzima hamwe no kwanduza ingirabuzimafatizo byerekanaga ubwiyongere bw'igice cya apoptotic sub-G1.Kuvura MHCC97-H hamwe na K bivanze na byo byatumye igabanuka rya mitochondrial membrane (Δψm) no kwangirika kwa ADN.Ubundi bushakashatsi bwerekanye ko ibice K byahinduye igipimo cya Fas, FasL, Bax / Bcl-2 hamwe na pro-caspase-9, pro-caspase-3 muburyo buterwa na dose, kandi byanabujije fosifora ya Akt.Ibisubizo byerekana ko ifumbire K ibuza cyane ikwirakwizwa ry’uturemangingo kandi igatera apoptose mu tugari twa MHCC97-H binyuze muri Fas- na mitochondria-yunganirwa na caspase-iterwa n'inzira mu ngirabuzimafatizo za HCC.