Ibicuruzwa

Amatsinda atatu yinguge ya cynomolgus akuze (Macaca fascicularis) yahuye na microgrammes 200 / m3 ammonium hexachloroplatinate [(NH4) 2PtCl6], microgramu 200 (NH4) 2PtCl6 icyarimwe hamwe na 1 ppm ozone (O3), cyangwa kuri 1 ppm O3 gusa.Inyamaswa zagaragajwe no guhumeka kumasaha 6 h kumunsi, iminsi 5 mucyumweru kuri 12 wk.Igishushanyo mbonera cyarimo methacholine preexposure hamwe na Na2PtCl6 isuzuma ryikibazo cya bronchoprovocation, ibizamini byuruhu rwa Na2PtCl6, hamwe na sera yo gusesengura antibodies.Ibyumweru bibiri nyuma ya 12-wk yerekanwe, ibyo bipimo bimwe byongeye gusubirwamo.Imikorere yibihaha ntabwo yigeze ihindurwa cyane nuburyo bwo kwerekana;icyakora, guhuza guhura na O3 na (NH4) 2PtCl6 byagabanije cyane kwibumbira hamwe umunyu wa platine (Pt) na methacholine ukenewe kugirango wongere impuzandengo yimpanuka (RL) 200% (EC200 RL).Ozone cyangwa Pt kwerekanwa byonyine nta ngaruka nini byagize kuri ibi bipimo.Platinum na methacholine EC200 RL indangagaciro zahujwe cyane mumatsinda yombi Pt yerekanwe nyuma yo kugaragara.Aya makuru yerekanaga ko guhuza O3 na Pt byiyongereye cyane (Pt) hamwe na hyperreactivite idasanzwe (methacholine) ya bronchial hyperreactivite kuruta guhura na O3 cyangwa umunyu wa Pt wenyine.Hamwe na O3 wongeyeho Pt guhura nabyo byongera cyane kwandura kwipimisha uruhu rwiza rwa Pt mugihe ugereranije nandi matsinda yerekanwe.Kimwe nubunararibonye bwabantu, kwipimisha radioallergosorbent (RAST) kuri antibodi yihariye ya Pt ntibyari byoroshye nko gupima uruhu rutaziguye mu kumenya abantu ba allergique.