Albendazole Cas: 54965-21-8
| Umubare wa Cataloge | XD91873 |
| izina RY'IGICURUZWA | Albendazole |
| URUBANZA | 54965-21-8 |
| Imiterere ya molekularila | C12H15N3O2S |
| Uburemere bwa molekile | 265.33 |
| Ibisobanuro birambuye | 2-8 ° C. |
| Amategeko agenga ibiciro | 29332990 |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu ya kirisiti yera |
| Assay | 99% min |
| Ingingo yo gushonga | 208-210 ° C. |
| ubucucike | 1.2561 (igereranya) |
| indangagaciro | 1.6740 (igereranya) |
| gukemura | Muburyo budashobora gushonga mumazi, gushonga kubusa muri acide ya anhidrous formic, gushonga gake cyane muri methylene chloride, muburyo budashonga muri Ethanol (96%). |
| pka | 10.72 ± 0.10 (Byahanuwe) |
| Amazi meza | 0,75mg / L (209 ºC) |
Albendazole numuti ukoreshwa mukuvura indwara ziterwa na parasite.Irashobora gutangwa kugirango ivure ubwonko budasanzwe (neurocysticercose) cyangwa irashobora gutangwa kugirango ivure indwara ya parasitike itera impiswi zikomeye (microsporidiose).
Ibikomoka kuri benzimidazole, albendazole nibiyobyabwenge bifite antihelmintique yagutse.Irerekana ingaruka ya antihelmintique irwanya cestode na nematode yunvikana muguhagarika inzira yo gufata glucose na parasite, ibyo bikaba bigaragarira mukugabanuka kwa glycogene no kugabanuka kurwego rwa adenosintriphophate.Nkigisubizo, parasite ihagarika kugenda irapfa.Ikoreshwa mugihe cyanduye Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, na Trichuris trichiura.Synonyme yibi biyobyabwenge ni SKF 62979 nibindi.
Methyl 5- (propylthio) -2-benzimidazolecarbamate (Eskazole, Zentel) ni anthelmintic yagutse itagaragaye muri Amerika ya ruguru.Iraboneka kuva muruganda rukora impuhwe zifatizo.Albendazole ikoreshwa henshi kwisi kugirango ivure kwandura amara.Nibyiza nkumuti umwe wo kuvura asikariyasi, Indwara Nshya na Kera Isi yanduye, na trichuriasis.Kuvura inshuro nyinshi hamwe na albendazole caneradicate pinworm, urudodo, capillariasis, clonorchiasis, n'indwara ya hydatide.Imikorere ya albendazole irwanya imiti (cestode) muri rusange irahinduka kandi idashimishije.
Albendazole ibaho nkifu ya kristaline yera idashobora gushonga mumazi.Kwinjira mu kanwa kwa albendazoleis byongerewe ifunguro rinini.Uyu muti uhura nihuta kandi nini ya mbere ya metabolisme ya sulfoxide, iyo ikaba ari uburyo bukora muri plasma.Kurandura igice cyubuzima bwa sulfoxide kuva kumasaha 10 kugeza 15.Hafi ya biliaryexcretion na enterohepatic recycling ya albendazolesulfoxide ibaho.Albendazole muri rusange yihanganira imiti imwe yo kuvura nematode yo munda.Ubuvuzi bukabije, buvura igihe kirekire busabwa mu kuvura indwara ya clonorchiasis orechinococcal ishobora kuvura ingaruka mbi nko kwiheba kw'amagufwa, kuzamuka kw'imisemburo ya hepatike, na alopecia.
Albendazole ifite ibikorwa byinshi byo kurwanya nematode yo munda na cestode, hamwe n'umwijima uhindura Opisthorchis sinensis, Opisthorchis viverrini, na Clonorchis sinensis.Yakoreshejwe kandi neza kurwanya Giardia lamblia.Albendazole nubuvuzi bwiza bwindwara ya hydatide cyst (echinococcose), cyane cyane iyo iherekejwe na praziquantel.Ifite kandi akamaro mu kuvura ubwonko n’umugongo neurocysticercose, cyane cyane iyo itanzwe na dexamethasone.Albendazole irasabwa kuvura gnathostomiasis.
