Ibicuruzwa

Ibimenyetso biheruka gushigikira uruhare rugaragara rwa β-nicotinamide adenine dinucleotide (β-NAD (+)) nkikinyamakuru cyitwa neurotransmitter na neuromodulator muri sisitemu ya nervice periferique -β-NAD (+) irekurwa mumyiteguro yimitsi yoroheje ya selile na chromaffin adrenal muburyo buranga neurotransmitter.Kugeza ubu ntibisobanutse niba ibi bifite ukuri kuri CNS.Twifashishije akazu gato ka superfusion assay hamwe na sensibilité yo hejuru yumuvuduko ukabije wamazi ya chromatografiya, twerekana ko gukurura-K (+) gukurura imbeba ya synaptosomes yimbeba itera ubwinshi bwa β-NAD (+), adenosine 5'-triphosphate, hamwe nazo metabolite adenosine 5'-diphosphate (ADP), adenosine 5'-monofosifate, adenosine, ADP-ribose (ADPR) na ADPR cycle.Hejuru-K (+) -yuzuye yuzuye ya β-NAD (+) ihujwe no gutandukanya SNAP-25 hamwe na botulineum neurotoxine A, kubuza imiyoboro ya N-voltage iterwa na Ca (2+) hamwe na ω-conotoxine GVIA , hamwe no kubuza proton gradient ya synaptic viticles hamwe na bafilo mycin A1, byerekana ko β-NAD (+) ishobora kurekurwa hakoreshejwe viticle exocytose.Isesengura ry’iburengerazuba ryerekana ko CD38, poroteyine ikora cyane ihinduranya β-NAD (+), ihari kuri synaptosomal membrane no muri cytosol.Synaptosomes yuzuye itesha agaciro β-NAD (+).1, N. Muri cortical neuron ya progaramu ya local-NAD (+) itera Ca (2+) yihuta, birashoboka bitewe no kwinjira kwa Ca (2+).Kubwibyo, imbeba synaptosomes yubwonko irashobora kurekura cyane, gutesha agaciro no gufata β-NAD (+), na β-NAD (+) irashobora gukangura neuron ya postynaptic, ingingo zose zikenewe kugirango ikintu gifatwa nkumukandida neurotransmitter mubwonko.