Ibicuruzwa

1.Gukora iperereza niba adenosine diphosphate (ADP) iterwa na adenosine ishobora kubuza guteranya platine, cyane cyane imbere ya P2Y₁₂ antagonist, aho ingaruka za ADP kuri reseptor ya P2Y₁₂ zakumirwa. Igiteranyo cya platelet cyapimwe hasubijwe ko ukora reseptor ya trombine. peptide kubara platine ibara plasma ikungahaye kuri platine (PRP) namaraso yose imbere ya ADP hamwe na P2Y₁₂ antagonist cangrelor, prasugrel ikora metabolite, na ticagrelor.Imbere ya P2Y₁₂ antagonist, preincubation ya PRP hamwe na ADP yabujije guteranya;izi ngaruka zavanyweho na adenosine deaminase.Nta kubuza kwegeranya kwabayeho mumaraso yose usibye mugihe dipyridamole yongeweho kugirango ibuze adenosine gufata erythrocytes.Ingaruka za ADP muri PRP n'amaraso yose yiganye hakoreshejwe adenosine kandi byari bifitanye isano itaziguye n'impinduka zabaye muri cAMP (zasuzumwe na fosifori yo mu bwoko bwa vasodilator-fosifori).Ibisubizo byose byari bimwe hatitawe kuri P2Y₁₂ anton agonist yakoreshejwe.ADP ibuza guteranya platine imbere ya P2Y₁₂ antagonist binyuze muguhindura adenosine.Kubuzwa bibaho muri PRP ariko ntibiri mumaraso yose usibye mugihe adenosine ifata.Nta numwe mubarwanya P2Y₁₂ wize yiganye ingaruka za dipyridamole mubushakashatsi bwakozwe.

2.ADP ifatwa nka agoniste idafite imbaraga kubera ibisubizo bike byo guteranya itera muri vitro kuri physiologique yibitekerezo bya Ca (2+) idasanzwe ((Ca (2+)) (o)].Kugabanuka [Ca (2+)] (o) mu buryo butangaje byongera ADP iterwa no guteranya, ingaruka zatewe no kongera umusaruro wa tromboxane A (2).Ubu bushakashatsi bwasuzumye uruhare rwa ectonucleotidase muri [Ca (2+)] (o) -kwishingikiriza kumikorere ya platel.Kugabanya [Ca (2))Guhagarika tromboxane A (2) umusaruro hamwe na aspirine ntacyo byagize kuriyi [Ca (2+)] (o) -ubwigenge.Kwirinda kwangirika kwa ADP byakuyeho itandukaniro riri hagati ya physiologique yo hasi na physiologiya [Ca (2+)] (o) bivamo guteranya gukomeye kandi gukomeye mubihe byombi.Ibipimo bya ADP idasanzwe byerekana ko igabanuka ryagabanutse muri plasma na apyrase-irimo gine saline kuri micromolar ugereranije na milimolar [Ca (2+)] (o).Nkuko byavuzwe mbere, ibisekuru bya tromboxane A (2) byongerewe imbaraga muke [Ca (2+)] (o), icyakora ibi ntibyigenga kubikorwa bya ectonucleotidase (.) P2Y reseptor antagonist cangrelor na MRS2179 byerekanaga ko hakenewe P2Y (12). kuri ADP ihamye ikusanyirizwa hamwe, hamwe n'uruhare ruto kuri P2Y (1).Mu gusoza, Ca (2+) -bishingiye kubikorwa bya ectonucleotidase nikintu gikomeye kigena urugero rwo guteranya platine kuri ADP kandi bigomba kugenzurwa mubushakashatsi bwibikorwa bya P2Y.