Ibicuruzwa

Imiti myinshi igabanya ubukana yananiwe kurandura ibibyimba, biganisha ku kurwanya imiti no kongera indwara.Ibimenyetso bya Hedgehog bigira uruhare runini mugihe cyo gukura kwa emboro, ariko kandi bigira uruhare mu iterambere rya kanseri, gutera imbere, na metastasis.Umuyoboro wa Hedgehog Patched (Ptc) ni Hedgehog yerekana intego ya gene ikabije cyane muri selile nyinshi za kanseri.Hano, twerekana isano iri hagati ya Ptc no kurwanya chimiotherapie, kandi dutanga ubushishozi bushya mumikorere ya Ptc.Ptc yakuwe muri plasma membrane nyuma yo gukorana na ligand yayo ya Hedgehog, cyangwa nyuma yo kuvura ingirabuzimafatizo hamwe na Hedgehog yerekana antagonist cyclopamine.Muri ubwo buryo bwombi, nyuma yubushakashatsi bwa selile hamwe na doxorubicin, imiti ya chimiotherapeutique ikoreshwa mugucunga amavuriro ya kanseri yisubiramo, twabonye ko habujijwe kwanduza doxorubicine kuva fibroblast isubiza Hedgehog, no kwiyongera kwa doxorubicine muri kanseri ebyiri zitandukanye. imirongo ya selile izwiho kwerekana aber rant urwego rwibihuru byerekana ibimenyetso.Twifashishije uburyo bwo kwerekana imvugo itandukanye, twerekanye byimazeyo ko imvugo ya Ptc yabantu yatanze imbaraga zo kurwanya imikurire yimiti ikoresheje imiti myinshi ivura imiti nka doxorubicin, methotrexate, temozolomide, na 5-fluorouracil.Kurwanya doxorubicin bifitanye isano n'imikorere ya Ptc, nkuko bigaragara hakoreshejwe ihinduka ry’imiterere y’abarwayi ba syndrome ya Gorlin aho ingaruka za Ptc zahujwe n’ikimenyetso cya Hedgehog zabuze.Ibisubizo byacu byerekana ko Ptc igira uruhare mu kurwanya ibiyobyabwenge no kurwanya imiti myinshi, kandi byerekana ko Ptc igira uruhare mu kurwanya imiti ya kanseri ya kanseri.