Ibicuruzwa

Imiterere ya Acyl-CoA itangiza selile fatty selile metabolism.Acyl-CoAs itangwa no guhuza aside irike kuri Coenzyme A yahujwe numuryango munini wa synthetase ya acyl-CoA (ACS).Ibinyuranye, acyl-CoAs irashobora gutwarwa numuryango wa acyl-CoA thioesterase (ACOT).Hano, twagennye amabwiriza yo kwandukura ya enzymes zose za ACS na ACOT hirya no hino no gusubiza ibibazo bya metabolike.Turasangamo uburyo bwo guhuza ibikorwa hagati yiyi miryango no hagati yimiryango ya gene kimwe nubuyobozi butandukanye bubaho mubice-na physiologique-biterwa na physiologique.Bitewe nimpinduka zagaragaye mumurongo muremure ACOT mRNA hamwe na proteine ​​nyinshi mu mwijima no mu mubiri wa adipose, twagaragaje ingaruka zo kongera ibikorwa bya cytosolike ndende-ya-thioesterase yibikorwa bya metabolisme ya aside irike muri utwo turemangingo tubyara imbeba za transgenji zikabije bikabije bikabije bya Acot7 muri umwijima cyangwa adipose tissue.Kwikuba kabiri cytosoliki acyl-CoA thioesterase yananiwe kurinda mic e umubyibuho ukabije uterwa nimirire, umwijima wamavuta cyangwa insuline irwanya insuline, ariko, gukabya gukabije kwa Acot7 muri adipocytes byatumye imbeba zihanganira ubukonje.Hamwe na hamwe, aya makuru yerekana uburyo butandukanye bwo kugenzura imisemburo ya ACS na ACOT kandi ko iyo misemburo ikora muburyo bwahujwe kugirango igabanye metaboliside ya fatide mu buryo bushingiye ku ngingo.