5-Nitro-1,10-phenanthroline CAS: 4199-88-6 Umuhondo wijimye kugeza kristu yijimye
| Umubare wa Cataloge | XD90385 |
| izina RY'IGICURUZWA | 5-Nitro-1,10-phenanthroline |
| URUBANZA | 4199-88-6 |
| Inzira ya molekulari | C12H7N3O2 |
| Uburemere bwa molekile | 225.21 |
Kugaragaza ibicuruzwa
| Ingingo yo gushonga | 200 - 203 ° C. |
| Suzuma | 99% |
| Kugaragara | Umuhondo wijimye kugeza kuri kirisiti |
Platinum 15 (II) ishingiye kuri metallointercalator yashizwe hamwe ikoresha ligande yasimbuwe 1,10-fenantroline (fen), harimo 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-fenantroline (5-NH2-phen), 5-nitro-1,10-fenantroline (5-NO2-phen) na dipyrido [3,2-d : 2 ', 3' .Cytotoxicité yabo mumurongo wa selile L1210 murine leukemia yagenwe hakoreshejwe uburyo bwo kubuza gukura.Ibyuma byinshi bya cytotoxique nibyinshi birimo S, S-dach bifasha ligande na 5-CH3-fen ihuza ligande.Metallointercalator imwe [Pt (5-CH3-phen) (S, S-dach)] Cl2 (5MESS), yerekana ubwiyongere bwikubye inshuro 5-10 cytotoxicity ugereranije nubuvuzi bwa cisplatine.Uhereye kubushakashatsi bwa ADN buhuza bigaragara ko nta tandukaniro rinini riri hagati yimwe mubyuma, byerekana ko nta ADN ihuza isano cyangwa uburyo bwo guhuza / ADN yakozwe ari yo yonyine igena cytotoxicitike yuyu muryango wa platine (II) ishingiye metallointercalators.
