Ibicuruzwa

(4R-Cis) -1,1-Dimethylethyl-6- [2- [2- (4-fluorophenil) -1-yl] ethyl] -2,2-dimethyl-1,3-dioxane-4-acetate ni uruganda rufite imiterere yimiti igoye.Mugihe amakuru yihariye kumikoreshereze yuru ruganda ashobora kuba make, turashobora kuganira kubishobora gukoreshwa dushingiye kumiterere yimiterere hamwe nibisanzwe biranga ibimera bisa. Kubaho kwa dioxyde de dioxyde muri iki kigo byerekana ko ishobora kuba ifite imitungo ya solve cyangwa ikoreshwa nk'umukozi wo gukemura ibibazo.Dioxane ni umusemburo usanzwe, cyane cyane muri chimie organic, kubera ko utaboneka neza kandi ukaba ufite imbaraga zo gukemura neza kuri molekile nyinshi.Kubaho kwa dioxyde de dioxyde muri uru ruganda byerekana ko ishobora kuba ifite ibintu bisa nkibishobora gukemuka.Ikindi kandi, ibice bigize imiterere yuru ruganda, nka fluorophenyl na fenilamino karubone, byerekana ibikorwa byibinyabuzima.Gusimbuza florine mu binyabuzima bishobora kongera imiti ya farumasi, bishobora kongera imbaraga cyangwa bioavailability.Kuba hari itsinda rya karuboni ya fenylamino irashobora kwerekana ubushobozi bwo gukorana nintego z’ibinyabuzima, bikaba bishoboka ko biganisha ku ngaruka zo kuvura.Bishingiye kuri ibi bintu byubatswe, birashoboka ko uru ruganda rushobora kugira imiti muri chimie yubuvuzi cyangwa guteza imbere ibiyobyabwenge.Irashobora gushakishwa nkibishobora kuba intandaro yo guteza imbere imiti mishya yibasira indwara zihariye.Icyakora, ni ngombwa kumenya ko hakenewe ubundi bushakashatsi kugira ngo hamenyekane imiterere nyayo ya farumasi, harimo imikorere yayo, uburyo bwo gukora, n'ingaruka zishobora guterwa. Usibye imiti y’imiti, iyi nitronyl cyangwa pyrrole moiety ishobora gutanga ibitekerezo mu bumenyi bwa siyansi. cyangwa nkibigize muri synthesis ya chimique.Ibikomoka kuri Nitronyl na pyrrole byakorewe iperereza kubishobora gukoreshwa nkibiyobora kama, catalizator, cyangwa kubaka inyubako zubaka.Ariko, izi porogaramu zisaba ubundi iperereza no kunoza uburyo bwa synthesis.Muri rusange, ibice (4R-Cis) -1,1-Dimethylethyl-6- [2- [2- (4-fluorophenyl) -5- (1- methylethyl) -3-fenyl-4 - ibikoresho siyanse, cyangwa synthesis.Nyamara, ni ngombwa gukora ubushakashatsi bwimbitse kugirango dusuzume imiterere yabwo, utezimbere inzira ikwiye, kandi tumenye uburyo bwihariye muri buri gice.