Ibicuruzwa

4 " n'ubushakashatsi mu bya farumasi. Bumwe mu buryo bwibanze bwa 4 '' - Propyl-3-fluorobiphenyl-4-boronic aside iri mu nzibacyuho ya catalizike ihuza reaction.Uru ruganda rushobora gukora nka acide ya boronic yubaka, ituma habaho gushiraho karubone-karubone cyangwa karubone-heteroatom.Kurugero, irashobora gukoreshwa muri reaction ya Suzuki-Miyaura, aho ikora hamwe na aryl cyangwa vinyl halide munsi ya palladium catalizike kugirango itange ibice bibiri.Izi ngaruka zifatika zikoreshwa cyane muguhuza molekile zigoye, harimo imiti, imiti yubuhinzi, nibikoresho.Hariho atome ya fluor muri 4 '' - Propyl-3-fluorobiphenyl-4-boronic aside yongerera imiterere yimpumuro nziza kandi itanga amahirwe yihariye yo guteza imbere ibikoresho bikora.Gusimbuza fluor birashobora kugira ingaruka zikomeye kumiterere ya fiziki ya chimique ya molekile, nko gukwirakwiza electronique na hydrophobicity.Iyi mitungo ikora ibikomoka kuri 4 '' - Propyl-3-fluorobiphenyl-4-boronic aside ifite akamaro mubikorwa bitandukanye, nka kristu y'amazi, OLEDs (diode organique itanga urumuri), nibindi bikoresho bya elegitoronike. Byongeye kandi, itsinda rya propyl muri imiterere ya 4 '' - Propyl-3-fluorobiphenyl-4-boronic aside itanga uburyo bworoshye bwo kubyara, itanga uburyo butandukanye bwibikomoka kumikorere.Ihindagurika rituma habaho guhuza ibice bitandukanye bifite imiterere n'imikorere.Ibikomokaho birashobora guhindurwa cyangwa kwinjizwa muburyo bunini bwa molekile kugirango habeho ibinyabuzima bigoye, molekile ya bioaktike, hamwe nibikoresho bigezweho.Mu bushakashatsi bwa farumasi, 4 '' - Propyl-3-fluorobiphenyl-4-boronic aside n'ibiyikomokaho byakorewe ubushakashatsi nkuko abashobora kuba abakandida kuvumbura ibiyobyabwenge.Ibikoresho bya florine bikunze kwerekana ihinduka ryimiterere ya metabolike, kongera lipofilicite, no guhindura ibikorwa byibinyabuzima ugereranije na bagenzi babo badafite florine.Kubwibyo, kwinjiza atome ya fluor muri molekile ikora mubinyabuzima irashobora kongera imiti ya farumasi, nkimbaraga noguhitamo.Mu gusoza, 4 '' - Propyl-3-fluorobiphenyl-4-boronic aside ifite akamaro gakomeye nkigihe cyo guhuza intungamubiri. , ibikoresho siyanse, nubushakashatsi bwa farumasi.Ubushobozi bwayo bwo kugira uruhare mubyerekezo byinzibacyuho bifatanyirizwa hamwe, ibintu bidasanzwe bifitanye isano no gusimbuza fluor, hamwe nubushobozi bwo kubikomokaho bituma iba igikoresho cyagaciro cyo kubyara molekile zigoye, ibikoresho bikora, hamwe n’abakandida ibiyobyabwenge.