4-Aminophthalhydrazide AMPPD Cas: 3682-14-2 Umuhondo wijimye kugeza amber kugeza ifu yicyatsi kibisi kugirango ibe
| Umubare wa Cataloge | XD90156 |
| izina RY'IGICURUZWA | 4-Aminophthalhydrazide |
| URUBANZA | 3682-14-2 |
| Inzira ya molekulari | C8H7N3O2 |
| Uburemere bwa molekile | 177.16 |
| Ibisobanuro birambuye | Ubike kuri RT |
Kugaragaza ibicuruzwa
| Kugaragara | Umuhondo wijimye kugeza amber kugeza ifu yicyatsi kibisi kugirango ibe |
| Assay | ≥98.0% |
| Ubucucike | 1.433 |
| Ingingo yo gushonga | 300 ºC |
| Ingingo yo guteka | 633 ° C kuri 760 mmHg |
| Ingingo ya Flash | 336.7 ° C. |
| Gukemura | Gukemura muri hydroxide ya amonium, karubone ya sodium cyangwa ikindi kintu. |
1.Twasesenguye kandi tugereranya ingaruka za H1-antihistamine eshanu kuri okiside iterwa na okiside iterwa no kurwego rwihariye kandi rudasanzwe rwimitsi ya polymorphonuclear leukocytes yumuntu kandi ikangurwa. Urutonde rwimbaraga za H1-antihistamine kugirango igabanye chemiluminescence yasuzumwe bidasanzwe: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine no kurubuga rudasanzwe: loratadine> dithiaden. - hamwe na site idasanzwe ya neutrophile yumuntu ikangura.
2.Chemiluminescence sisitemu yongerewe imbaraga na isoluminol cyangwa luminol ifatanije na peroxidase nuburyo bworoshye bwo kumenya ubwoko bwa ogisijeni ikora (ROS) ikorwa na fagocyte NADPH oxydease.Ibice bibiri byongera imbaraga birasa muburyo butandukanye, bitandukanye gusa mumwanya witsinda rya amino mumpeta ya aromatic ya molekile.Iri tandukaniro rihindura isoluminol molekile nkeya ya lipofilique itemewe cyane na biologiya.Gukoresha isoluminol rero bigarukira gusa kubushakashatsi bujyanye no gusohora metabolite ya ogisijeni.Muri ubu bushakashatsi twerekana ko peptide ya sintetike ikomoka kuri N-terminal ya calcium ya calcium igengwa na protein annexin AI ibangamira kumenya radicals muri isoluminol-yongerewe imbaraga, ariko ntabwo iri muri sisitemu ya luminol.Annexin AI ikomoka kuri peptide igabanya urumuri hamwe na isoluminol ishimishijwe na superoxide na horseradish peroxidase (HRP) muri formyl-methionyl-leucyl-phenylalanine- na forbol my ristate selile itera imbaraga, hamwe na hydrogen peroxide na HRP.Uburyo busobanutse bwo kubuza ntabwo buzwi.Ibisubizo byatanzwe byerekana neza ko kugabanuka kwa selile byagaragaye hamwe na chemiluminescence ya isoluminol yongerewe imbaraga bigomba kwemezwa hakoreshejwe ubundi buryo bwo kumenya irekurwa rya anion ya superoxide na hydrogen peroxide.
