Imbeba zatanzwe ikinini kimwe gikomoka ku bimera fenolike antioxydeant Quercetin (QC) ku buntu, liposome ikingiwe na liposome ya galaktosilate ifunze 2 h mbere ya dose ya hepatotoxic ya karbontetrachloride (CCl4, 40% v / v mu mavuta ya elayo, 1 ml / kg b b .wt).Muri ubwo buryo butatu bwa QC bwageragejwe, gusa QC ya galaktosilate ya liposomal QC yatanze uburinzi bukomeye bwo kwirinda CCl4 yangiza umwijima wa okiside.Nyuma ya 24 h yo gutera inshinge (SC) selile hepatike yimbeba byagaragaye ko ishobora kwanduzwa na CCl4 yangiza okiside kandi yakurikiranwe nubwiyongere bwa diene conjugated diane muri hepatike.Ubwiyongere bubiri bwa diene conjugated no kwinjiza CCl4 bwaragabanutse kugera kurwego rusanzwe na galactosylated liposomal QC mbere yo kuvura.Carbontetrachloride yateje membrane kwangirika kwingirangingo z'umwijima kandi byasuzumwe na serumu yamaraso patologue na tissue tissue histopathologique.Kwangirika kwa Membrane kwinjizwa na CCl4 byongeye gusuzumwa no kugabanuka kurwego rwa plasma membrane (PM) ihuza enzyme Na + / K + ATPase kandi yariyongereye gusa mbere yo kuvura liposomal QC ya galactosylated.Carbontetrachloride yatumye igabanuka ryinshi haba murwego rwa enzymatique na molekuline endogenous antioxydeant ya selile ya hepatike. Kwiheba muri sisitemu ya antioxydeant mu ngirabuzimafatizo ya hepatike byakumiriwe burundu n'umuti umwe wa liposomal QC mbere yo kuvura CCl4.Umwijima wafashwe na QC wagereranijwe nyuma ya 2 h yo guterwa flavonoide (8.9 micromol / kg uburemere bwumubiri) (form yubusa cyangwa liposomal) naho 85% ya QC yatewe yabonetse mu mwijima mugihe cya galaktosylated liposomal QC.Mugihe 25% byonyine byatewe inshinge byagaragaye mu mwijima mugihe inshinge zingana na QC yubusa.Carbontetrachloride nayo yatumye habaho ihinduka ryamazi ya membrane kandi byasuzumwe no kugabanuka kwa micro-viscosity.Ubuvuzi bwa QC mbere yubusa bwatumye nta burinzi bwa CCl4 butera ubwiyongere bw’amazi y’umwijima, mu gihe QC ya galactosylated liposomal QC yarinze cyane ubwiyongere.Ibyavuye muri ubu bushakashatsi byagaragaje ko QC muri liposome ya galactosylated ishobora kurinda cyane CCl4 yatewe n’imvune ya hepatocellular.
