Ibicuruzwa

(+) - (3R, 5S), tert-Butyl 7- [4- (4-fluorophenyl) -6-isopropyl-2- -dihydroxy-6 (E) -heptenate, izwi kandi nka R1.5 cyangwa tert-butyl-rosuvastatin, ni imiti ivanga imiti ishobora gukoreshwa mu nganda zimiti.Rosuvastatin numuti uzwi cyane wo kugabanya cholesterol ugabanya icyiciro. by'ibiyobyabwenge bita statine.Ikora muguhagarika enzyme yitwa HMG-CoA reductase, igira uruhare mukubyara cholesterol mumubiri.R1.5 ni inkomoko ya rosuvastatine irimo itsinda rya tert-butyl ifatanye na molekile, itanga imitungo yinyongera ninyungu zishobora kubaho. Kimwe mubishobora gukoreshwa R1.5 nikintu cya farumasi yo kuvura hyperlipidemiya no kwirinda indwara zifata umutima.Kimwe na rosuvastatin, R1.5 irashobora gukoreshwa kugirango igabanye urugero rwa cholesterol ya LDL, izwi kandi nka cholesterol "mbi", na triglyceride mu maraso.Uru ruganda rushobora kwerekana imiti ya farumasi ikoreshwa neza, nko kongera bioavailability cyangwa kongera umutekano, ugereranije nibiyobyabwenge byababyeyi.Ikigeretse kuri ibyo, itsinda rya tert-butyl rishobora kugira uruhare mu gukemura ibibazo no guhinduranya ibintu, bigatuma bikwiranye na sisitemu zitandukanye zo gutanga ibiyobyabwenge. Ubundi buryo bwo gukoresha R1.5 ni mugutezimbere prodrugs cyangwa uburyo bwo gutanga ibiyobyabwenge.Itsinda rya tert-butyl rirashobora gukora nk'itsinda ririnda, ryemerera kurekura rosuvastatine mu ngingo cyangwa ingingo zihariye, nk'umwijima.Izi ngamba zirashobora kongera imikorere yibiyobyabwenge kandi bikagabanya ingaruka zishobora guterwa no kongera aho zerekeza mugihe hagabanijwe guhura ningingo zidafite intego.Ikindi kandi, R1.5 irashobora kuba igikoresho cyingirakamaro kubashinzwe imiti mu kuvumbura no guteza imbere ibiyobyabwenge.Imiterere igoye itanga urubuga rwo gukomeza guhindura no gukuramo.Abashakashatsi barashobora gukoresha R1.5 nkurwego rwo kuyobora kugirango basuzume isano-mikorere-ibikorwa kandi batezimbere ibigereranyo bishya hamwe nimbaraga zongerewe imbaraga, guhitamo, cyangwa uburyo bwiza bwo kuvura.Ubushakashatsi nkubu burashobora kugira uruhare mugutezimbere ibishya hamwe na statin nziza cyangwa izindi miti igabanya cholesterol.Mu gusoza, (+) - (3R, 5S), tert-Butyl 7- [4- (4-fluorophenyl) -6-isopropyl -2-. kuvura hyperlipidemiya n'indwara z'umutima.Imiterere yihariye, ifatanije nitsinda rya tert-butyl, irashobora gutanga ibyiza nko kunoza imiti ya farumasi, gutanga imiti igamije, n'amahirwe yo kurushaho guteza imbere ibiyobyabwenge.Ubundi bushakashatsi niterambere birakenewe kugirango tumenye neza ubushobozi bwa R1.5 murwego rwa farumasi.