Ibicuruzwa

Acetoxy Empagliflozin, izwi kandi nka empagliflozin acetate, ni uburyo bwahinduwe bwibiyobyabwenge bya antidiabete empagliflozin.Empagliflozin ni iy'ibiyobyabwenge bizwi ku izina rya sodium-glucose co-transport 2 (SGLT2) inhibitor, zikoreshwa cyane cyane mu gucunga indwara ya diyabete yo mu bwoko bwa 2.Empagliflozin ikora ibuza SGLT2, poroteyine ishinzwe gusubiza glucose mu mpyiko.Muguhagarika iyi poroteyine, (3R, 4S, 5R, 6R) -3,4,5-tris (triMethylsilyloxy) -6 - ((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-imwe ni imiti igoye hamwe na a izina rirerire.Igwa munsi yicyiciro cya triMethylsilyloxy pyranone, ikoreshwa cyane mubikorwa bitandukanye bya siyansi ninganda.Bimwe mubintu byingenzi byakoreshejwe (3R, 4S, 5R, 6R) -3,4,5-tris (triMethylsilyloxy) -6- ( (triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-imwe ni nkitsinda ririnda synthesis.Kurinda amatsinda nitsinda ryimikorere ryigihe gito rikoreshwa mukurinda ibibanza byihariye bikora kuri molekile mugihe cyimiti.Kubireba (3R, 4S, 5R, 6R) -3,4,5-tris (triMethylsilyloxy) -6 - ((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-imwe, amatsinda ya triMethylsilyloxy akora nk'imitsi ikingira .Mugihe cyo kubyitwaramo, ayo matsinda arinda amatsinda amwe yimikorere kutagira ibyifuzo bitifuzwa, bigatuma ibyifuzo byifuzwa bigenda neza.Nyuma yo kubyitwaramo birangiye, amatsinda ya triMethylsilyloxy arashobora gukurwaho byoroshye, bikagaragaza amatsinda yambere akora.Ubundi buryo bwo gukoresha (3R, 4S, 5R, 6R) -3,4,5-tris (triMethylsilyloxy) -6 - ((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-imwe iri muri synthesis yibintu kama.Irashobora gukoreshwa nkinyubako yo kubaka inyubako zigoye.Imiterere yihariye ya chimique na reactivite bituma iba igikoresho cyagaciro mugutezimbere ibinyabuzima bishya.Abashinzwe imiti barashobora gukoresha (3R, 4S, 5R, 6R) -3,4,5-tris (triMethylsilyloxy) -6 - ((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-imwe kugirango bamenyekanishe amatsinda yihariye cyangwa bakora molekile yihariye scafolds yo kwiga ibikorwa byibinyabuzima byimvange cyangwa guteza imbere imiti mishya.Ikindi kandi, iyi nteruro irashobora kubona ibisabwa mubijyanye na siyansi yibintu.Kubaho kwayo nkitsinda rikora muri molekile irashobora gutanga ibintu bimwe byifuzwa kubikoresho.Kurugero, irashobora kongera imbaraga mumashanyarazi yihariye cyangwa igateza imbere imiterere ya firime, ikagira akamaro mugutwikira cyangwa gufatisha. (3R, 4S, 5R, 6R) -3,4,5-tris (triMethylsilyloxy) -6 - ((( triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-imwe ni uruganda rwihariye cyane rukoreshwa muburyo butandukanye mubumenyi butandukanye ninganda.Ubushobozi bwayo bwo gukora nk'itsinda ririnda kandi bukora nk'ibice byubaka muri chimie yubukorikori, hamwe nibishobora gukoreshwa mubumenyi bwa siyansi, bigira uruhare runini mugutezimbere molekile nshya nibikoresho.Ariko, uburyo bukoreshwa nuburyo bukoreshwa burashobora gutandukana, bitewe nibisabwa n'intego byihariye byumushinga wubumenyi cyangwa inganda.